Evidence map›Paper›PMID 40257612›Full record

ArticleEuropean journal of nuclear medicine and molecular imaging2025

Development and clinical evaluation of [

Weijing Tao, Jinglin Zhang, Xin Meng, Xuedong Han, Qiuhu Wang, Yixiang Lin, Luyi Cheng, Minmin Liu, Dongzhu Da, Huai Zhang and 6 more

Abstract read
PubMed Publisher
In one paragraph

Article in European journal of nuclear medicine and molecular imaging, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

16 authors.

Weijing Tao *Department of Nuclear Medicine, The Affiliated Huaian No. 1 People's Hospital of Nanjing Medical University, No. 1 Huanghe West Road, Huai'an, 223300, Jiangsu, China. weijingtao2021@vip.163.com.
Jinglin Zhang *Key Laboratory for Experimental Teratology of the Ministry of Education and Research Center for Experimental Nuclear Medicine, School of Basic Medical Sciences, Shandong University, No. 44 Wenhua Xi Road, Jinan, 250012, Shandong, China.
Xin Meng *Department of Breast and Thyroid Surgery, The Huai'an Clinical College of Xuzhou Medical University, Huai'an, 223300, Jiangsu, China.
Xuedong Han *Department of Breast and Thyroid Surgery, The Affiliated Huaian No. 1 People's Hospital of Nanjing Medical University, No. 1 Huanghe West Road, Huai'an, Jiangsu, 223300, China.
Qiuhu WangDepartment of Nuclear Medicine, The Affiliated Huaian No. 1 People's Hospital of Nanjing Medical University, No. 1 Huanghe West Road, Huai'an, 223300, Jiangsu, China.
Yixiang LinKey Laboratory for Experimental Teratology of the Ministry of Education and Research Center for Experimental Nuclear Medicine, School of Basic Medical Sciences, Shandong University, No. 44 Wenhua Xi Road, Jinan, 250012, Shandong, China.
Luyi ChengDepartment of Nuclear Medicine, The Affiliated Huaian No. 1 People's Hospital of Nanjing Medical University, No. 1 Huanghe West Road, Huai'an, 223300, Jiangsu, China.
Minmin LiuDepartment of Breast and Thyroid Surgery, The Affiliated Huaian No. 1 People's Hospital of Nanjing Medical University, No. 1 Huanghe West Road, Huai'an, Jiangsu, 223300, China.
Dongzhu DaDepartment of Breast and Thyroid Surgery, The Affiliated Huaian No. 1 People's Hospital of Nanjing Medical University, No. 1 Huanghe West Road, Huai'an, Jiangsu, 223300, China.
Huai ZhangDepartment of Nuclear Medicine, The Affiliated Huaian No. 1 People's Hospital of Nanjing Medical University, No. 1 Huanghe West Road, Huai'an, 223300, Jiangsu, China.
Junfu FanDepartment of Nuclear Medicine, The Affiliated Huaian No. 1 People's Hospital of Nanjing Medical University, No. 1 Huanghe West Road, Huai'an, 223300, Jiangsu, China.
Lianmei ZhangDepartment of Pathology, The Affiliated Huaian No. 1 People's Hospital of Nanjing Medical University, No. 1 Huanghe West Road, Huai'an, 223300, Jiangsu, China.
Shuangyue LiuDepartment of Breast and Thyroid Surgery, The Affiliated Huaian No. 1 People's Hospital of Nanjing Medical University, No. 1 Huanghe West Road, Huai'an, Jiangsu, 223300, China.
Shuo LiDepartment of Breast and Thyroid Surgery, The Affiliated Huaian No. 1 People's Hospital of Nanjing Medical University, No. 1 Huanghe West Road, Huai'an, Jiangsu, 223300, China.
Feng GaoKey Laboratory for Experimental Teratology of the Ministry of Education and Research Center for Experimental Nuclear Medicine, School of Basic Medical Sciences, Shandong University, No. 44 Wenhua Xi Road, Jinan, 250012, Shandong, China. rggaofeng@sdu.edu.cn.
Yi RenDepartment of Breast and Thyroid Surgery, The Huai'an Clinical College of Xuzhou Medical University, Huai'an, 223300, Jiangsu, China. only_renyi@163.com.

Funding

Chinese Society of Clinical Oncology 2024CICCPMHR018the project of Nanjing Medical University - Qilu Clinical Research Foundation and the project of Tumours Individualized Medical Cooperative Innovation Center by Nanjing Medical University KY218CXY2024019
6 · The paper itself

Abstract

purposeAccurate assessment of human epidermal growth factor receptor type 2 (HER2) expression is crucial for diagnosis, treatment planning, and monitoring of breast cancer patients. A

methodsThe gene encoding ADAPT6 was modified with N-terminal (GHEHEHEDANS) and C-terminal (GSSC) extensions to enhance its functionality. The precursor was synthesized, purified, and characterized, followed by radiolabeling with

resultsThe tracer was prepared with a radiochemical purity exceeding 99% and demonstrated high stability in vivo. Micro-PET/CT imaging revealed significant accumulation of the radiotracer in HCC1954 tumors, which was markedly reduced after HER2 blockade with trastuzumab. In contrast, MDA-MB-468 tumors showed minimal uptake. In the clinical study, [

conclusion[

Indexed as

AcetatesBreast NeoplasmsErb-b2 Receptor Tyrosine KinasesGallium RadioisotopesHeterocyclic CompoundsHeterocyclic Compounds, 1-RingPositron-Emission TomographyPositron Emission Tomography Computed TomographyRadiopharmaceuticalsAnimalsCell Line, TumorFemaleHumansMiceMiddle AgedRadioactive Tracers1-(1,3-carboxypropyl)-4,7-carboxymethyl-1,4,7-triazacyclononaneAcetatesERBB2 protein, humanErb-b2 Receptor Tyrosine KinasesGallium-68Gallium RadioisotopesHeterocyclic CompoundsHeterocyclic Compounds, 1-RingRadioactive TracersRadiopharmaceuticals68GaADAPT6Breast cancerHER2Positron emission tomography (PET)

Identifiers

PMID40257612

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.