Evidence map›Paper›PMID 40257604›Full record

ArticleDiscover oncology2025

Comprehensive analysis of mRNA expression of Piezo1 and Piezo2 in tumor samples and their prognostic implications in gastric cancer.

Tong Liang, Junhong Wang, Zhong Yang, Ronglong Zhang

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Discover oncology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed.

  1. Review
  2. Piezo channels in tumors.Journal of cancer research and clinical oncology · 2026
    Review
  3. Review
  4. Review
  5. PIEZO2 in tumors: from mechanobiological switches to activity-targeted therapies.Journal of experimental & clinical cancer research : CR · 2025
    Review
  6. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Tong Liang *The First School of Clinical Medicine, Lanzhou University, Lanzhou, 730000, Gansu, China. liangt21@lzu.edu.cn.
Junhong WangThe First School of Clinical Medicine, Lanzhou University, Lanzhou, 730000, Gansu, China.
Zhong Yang *Department of Surgical Oncology, Gansu Provincial Hospital, Lanzhou, 730000, Gansu, China. yxyangz@163.com.
Ronglong Zhang *General Surgical Department, The First People's Hospital of Baiyin, Baiyin, 730900, Gansu, China. zhangronglong269@outlook.com.

Funding

Intramural Research Fund Project of Gansu Provincial People's Hospital 23GSSYF-37the Gansu Provincial Science and Technology Plan 23JRRA1777the Intramural Research Fund Project of Gansu Provincial People's Hospital, the Key Laboratory of Gastrointestinal Tumour Diagnosis and Treatment of the National Health and Health Commission 23GSSYA-18
6 · The paper itself

Abstract

backgroundThis study aims to investigate the expression pattern and clinical significance of Piezo1 and Piezo2 in various cancers, focusing on gastric cancer (GC).

methodsThe study investigated the mRNA expression levels of Piezo1 and Piezo2 in tumor samples from different cancers using the BEST online database. The case-control studies about the relation between Piezo1 and Piezo2 and GC were retrieved from PubMed, Embase, Web of Science, and Cochrane Library. The retrieval time was from inception to October, 2023. The meta-analysis of the included literatures was conducted by the STATA 12.0 software. Additionally, the expression profiles of Piezo1 and Piezo2 in tumor and normal gastric tissues were analyzed, and their clinical drug relevance was assessed using the CPADS database. The research program has been registered with PROSPERO (CRD42023495836).

resultsThe analysis demonstrated elevated mRNA expression of both Piezo1 and Piezo2 in the majority of tumor samples. Of particular note was the significant increase observed in GC tissue compared to normal tissue (all p < 0.05). Additionally, the meta-analysis revealed a meaningful correlation between high expression levels of Piezo1 and Piezo2 and poor prognosis in patients with GC (HR = 1.48, 95% CI = 1.27-1.69, p < 0.0001). This study identified a significant correlation between high levels of Piezo1 expression and the TNM phase (OR = 1.87, 95% CI = 1.21-2.91, p = 0.005). Furthermore, enhanced Piezo2 expression was observed to be positively correlated with survival status (OR = 2.12, 95% CI = 1.31-3.44, p = 0.002). Piezo1 (p = 0.028, R

conclusionThe findings of this study indicate that the expression levels of Piezo1 and Piezo2 have the potential to serve as diagnostic indicators or therapeutic targets for GC management.

trial registrationCRD42023495836 (PROSPERO).

Indexed as

DiagnosisGastric cancerPiezo1Piezo2Prognosis

Identifiers

PMID40257604
PMCPMC12011698

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