Evidence map›Paper›PMID 40257593›Full record

Trial reportSupportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer2025

Effectiveness of advanced platelet-rich fibrin on post-exodontia socket healing in patients who had undergone head and neck radiation.

Dhiancarlo Rocha Macedo, Jéssica Ferreira Rodrigues, Luiz Fernando Barbosa de Paulo, Guilherme José Pimentel Lopes de Oliveira, Priscilla Barbosa Ferreira Soares

Abstract readRandomized Controlled Trial
PubMed Publisher
In one paragraph

Trial report in Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Dhiancarlo Rocha MacedoSchool of Dentistry, Graduate Program in Dentistry, Hospital Dentistry Area, Federal University of Uberlandia, Uberlandia, MG, Brazil.ORCID http://orcid.org/0000-0002-9241-5187
Jéssica Ferreira RodriguesSchool of Dentistry, Graduate Program in Dentistry, Federal University of Uberlandia, Uberlandia, MG, Brazil.ORCID http://orcid.org/0000-0003-2352-6497
Luiz Fernando Barbosa de PauloSchool of Dentistry, Hospital Dentistry Area, Federal University of Uberlandia, Uberlandia, MG, Brazil.ORCID http://orcid.org/0000-0003-1146-0777
Guilherme José Pimentel Lopes de OliveiraSchool of Dentistry, Graduate Program of Dentistry, Periodontics and Implant Dentistry, Federal University of Uberlandia, Uberlandia, MG, Brazil.ORCID http://orcid.org/0000-0001-8778-0115
Priscilla Barbosa Ferreira SoaresSchool of Dentistry, Graduate Program of Dentistry, Periodontics and Implant Dentistry, Federal University of Uberlandia, Uberlandia, MG, Brazil. pbfsoares@yahoo.com.br.ORCID http://orcid.org/0000-0002-4492-8957

Funding

Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq) - INCT Saúde Oral e Odontologia Grants n. 406840/2022-9.Coordenação de Aperfeiçoamento de Pessoal de Nível Superior CAPES #001
6 · The paper itself

Abstract

objectiveOsteoradionecrosis (ORN) of the jaw is one of the most significant complications of radiotherapy (RT) for head and neck cancer (HNC), and is primarily attributable to tooth extraction. The objective of this study was to assess the efficacy of advanced platelet-rich fibrin (A-PRF) in preventing ORN after tooth extraction in patients with post-irradiated HNC and other postoperative complications.

methodsThe study population comprised 30 patients who previously underwent radiotherapy for HNC and subsequently underwent tooth extraction, with a total of 134 extractions performed. Extraction sockets were randomly assigned to receive either A-PRF (n = 67 [experimental group]); or clot maintenance alone (n = 67 [control group]). Patients were clinically evaluated at 7, 14, 30, 60, 90, and 120 days postoperatively to assess pain and healing of the surgical site. The intensity of postoperative pain was quantified using a visual analog scale. Patients were clinically evaluated for up to 120 days to diagnose ORN. Other postoperative complications, including edema, bleeding, tissue color, consistency, and suppuration, were also evaluated.

resultsIn terms of pain and healing, there was no statistically significant difference between the two groups. No ORN or other surgical complications were observed. The use of A-PRF demonstrated no statistically significant differences compared with the control group in most of the parameters evaluated.

conclusionA-PRF yielded no additional benefits and did not influence the healing process in the short or medium term. RBR- 3 TDK22P: Date of registration: 02/14/2022.

Indexed as

Head and Neck NeoplasmsOsteoradionecrosisPlatelet-Rich FibrinTooth ExtractionTooth SocketAdultAgedFemaleHumansMaleMiddle AgedPain MeasurementPostoperative ComplicationsPostoperative PainWound HealingHead and neck cancerOsteoradionecrosisPlatelet-rich fibrinRadiotherapyTooth extraction

Identifiers

PMID40257593

What OpenQuestion holds

Textmetadata
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.