ArticleNeurochemical research2025
Electroacupuncture Ameliorates Chronic Inflammatory Pain and Depression Comorbidity by Inhibiting Nrf2-Mediated Ferroptosis in Hippocampal Neurons.
Article in Neurochemical research, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers, 1 of them a synthesis that pooled it.
What it found
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The trial behind it
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Who cites it
7 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Effectiveness of Digital Cognitive Behavioural Therapy (dCBT) for Co-Occurring Anxiety, Depression and Chronic Pain in Adults: A Systematic Review and Meta-Analysis.Actas espanolas de psiquiatria · 2026Pooled it
- Ferroptosis in major depressive disorder: Molecular mechanisms, cellular vulnerability, and therapeutic opportunities.Biochemistry and biophysics reports · 2026Review
- Hippocampal Neuronal Ferroptosis Driven by Lipocalin-2 Mediates Comorbid Visceral Pain and Anxiety in Irritable Bowel Syndrome.Molecular neurobiology · 2026Article
- Electroacupuncture for trigeminal neuralgia with anxiety disorders: study protocol for a randomized controlled trial.Frontiers in medicine · 2026Article
- Electroacupuncture Pretreatment Ameliorates Perioperative Neurocognitive Disorder in Aged Mice by Inhibiting Ferroptosis Through the SIRT1/NRF2/GPX4 Pathway.Journal of cellular and molecular medicine · 2026Article
- Stage-Specific Mechanisms of Manual Acupuncture and Electroacupuncture in Inflammatory Pain: A Time-Dependent Review.Journal of pain research · 2026Review
- The relationship between chronic pain and health-related quality of life: the mediating roles of frailty and depression in chronic disease patients.Frontiers in public health · 2025Article
Corrections and comments
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Authors and funding
5 authors.
Funding
Abstract
Chronic inflammatory pain and depression are highly comorbid, with nuclear factor erythroid 2-related factor 2 (Nrf2)-mediated ferroptosis in hippocampal neurons strongly associated with the onset and progression of the comorbidity. Electroacupuncture (EA), widely used to treat pain and mood disorders, may ameliorate chronic inflammatory pain and depression comorbidity (CIPDC) by inhibiting Nrf2-mediated ferroptosis in hippocampal neurons, though its mechanism of action remains partially understood. In this study, we established the CIPDC model by administering a subcutaneous injection of complete Freund's adjuvant (CFA) into the left hind paw. Evaluations of EA's effects on pain thresholds and depressive behaviors in CIPDC rats included paw withdrawal mechanical threshold, paw withdrawal thermal latency, sucrose preference test, open field test, and forced swim test assessments. HE staining was performed to assess the pathological and morphological alterations in hippocampal neurons. FJB staining was utilized to evaluate neuronal degeneration, while transmission electron microscopy (TEM) was employed to examine ultrastructural changes in hippocampal neuronal mitochondria. Prussian blue staining was conducted to visualize ferrous ion deposition in the hippocampus, and the contents of ferrous ion (Fe
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40257585What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.