Evidence map›Paper›PMID 40257579›Full record

Trial reportEuropean archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery2025

Efficacy of nasal saline irrigation in conjunction with intranasal steroids in allergic rhinitis.

Omvir Singh Chahar, Sheetal Raina, Ahmad Rizwan, Supreet Singh Nayyar, Shailendra Tripathi, Akshay Bhatnagar, Ombir Singh, Nandini Bisht, Mohneesh Dixit

Abstract readRandomized Controlled Trial
PubMed Publisher
In one paragraph

Trial report in European archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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1 · What the graph read from it

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2 · The registry

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3 · Its place in the literature

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4 · The record

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5 · Who and what money

Authors and funding

9 authors.

Omvir Singh ChaharDepartment of Otorhinolaryngology & Head Neck Surgery, Command Hospital Central Command, Lucknow, Uttar Pradesh, 226002, India.
Sheetal RainaDepartment of Otorhinolaryngology & Head Neck Surgery, Command Hospital Central Command, Lucknow, Uttar Pradesh, 226002, India.
Ahmad RizwanDepartment of Otorhinolaryngology & Head Neck Surgery, Command Hospital Central Command, Lucknow, Uttar Pradesh, 226002, India.
Supreet Singh NayyarDepartment of Otorhinolaryngology & Head Neck Surgery, Command Hospital Central Command, Lucknow, Uttar Pradesh, 226002, India. ssnayyar@gmail.com.ORCID http://orcid.org/0000-0002-5982-6902
Shailendra TripathiDepartment of Otorhinolaryngology & Head Neck Surgery, Command Hospital Central Command, Lucknow, Uttar Pradesh, 226002, India.
Akshay BhatnagarDepartment of Otorhinolaryngology & Head Neck Surgery, Command Hospital Central Command, Lucknow, Uttar Pradesh, 226002, India.
Ombir SinghDepartment of Otorhinolaryngology & Head Neck Surgery, Command Hospital Central Command, Lucknow, Uttar Pradesh, 226002, India.
Nandini BishtDepartment of Otorhinolaryngology & Head Neck Surgery, Command Hospital Central Command, Lucknow, Uttar Pradesh, 226002, India.
Mohneesh DixitDepartment of Otorhinolaryngology & Head Neck Surgery, Command Hospital Central Command, Lucknow, Uttar Pradesh, 226002, India.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

aimTo study the efficacy of nasal saline irrigation combined with intranasal corticosteroids in treating Allergic Rhinitis and compare it with intranasal corticosteroids alone. METHODOLOGY: A prospective, randomized trial conducted at a tertiary care center. Symptomatic individuals diagnosed with Allergic Rhinitis were included. The control group received fluticasone propionate nasal spray (200 mcg/day) and the treatment group received fluticasone propionate nasal spray (200 mcg/day) along with nasal saline irrigation with isotonic normal saline (50 ml/nostril with each irrigation thrice a day). The two groups were followed up for 12 weeks. The outcome was compared using a patient-reported experience measure "Allergic rhinitis scoring system".

resultsA total of 120 patients (60 in each group) were included in the study. Pre-intervention, there were no significant differences between the two groups with the Allergic rhinitis scoring system. Post-Intervention, significant improvements were evident across all assessed symptoms: rhinorrhoea (14.93 ± 4.16 vs. 17.80 ± 3.16, p < 0.0001), sneezing (14.40 ± 3.91 vs. 18.27 ± 3.16, p < 0.0001), nasal blockage (10.47 ± 4.66 vs. 13.80 ± 4.80, p = 0.0002), nasal pruritus (17.93 ± 3.17 vs. 19.13 ± 1.96, p = 0.0140), ocular pruritus (18.60 ± 2.84 vs. 19.13 ± 2.22, p = 0.2537), and total Allergic rhinitis scoring system score (77.00 ± 9.79 vs. 88.13 ± 7.70, p < 0.0001).

conclusionNasal saline irrigation used in conjunction with intranasal corticosteroids more effectively alleviates all symptoms of Allergic rhinitis. However, there was no significant difference in ocular pruritus in both groups.

trial registrationTrial registered with Clinical trial registry-India, CTRI/2023/01/048641. URL: https://ctri.nic.in/Clinicaltrials/main1.php?EncHid=44058.73881 .

Indexed as

Anti-Allergic AgentsFluticasoneNasal LavageRhinitis, AllergicSaline SolutionAdministration, IntranasalAdolescentAdultFemaleHumansMaleMiddle AgedNasal SpraysProspective StudiesTreatment OutcomeYoung AdultAnti-Allergic AgentsFluticasoneNasal SpraysSaline SolutionAllergic rhinitisAllergyIntranasal corticosteroidsNasal obstructionNormal saline nasal irrigationSneezing

Identifiers

PMID40257579

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.