Evidence map›Paper›PMID 40257526›Full record

ArticleVirchows Archiv : an international journal of pathology2026

NFIB::PHACTR2, a novel atypical fusion gene identified in adenoid cystic carcinoma of the palate.

Shuanzeng Wei, Akina Tamaki, Jianming Pei, Aldana Vistarop, Peter A McCue, Lu Chen, Douglas B Flieder

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In one paragraph

Article in Virchows Archiv : an international journal of pathology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Shuanzeng WeiDepartment of Pathology, Fox Chase Cancer Center, 333 Cottman Avenue, Philadelphia, PA, 19111, USA. weishuanzeng@hotmail.com.ORCID http://orcid.org/0000-0002-0441-6973
Akina TamakiDepartment of Otolaryngology-Head and Neck Surgery, Lewis Katz School of Medicine at Temple University, Fox Chase Cancer Center, Philadelphia, PA, 19111, USA.
Jianming PeiDepartment of Pathology, Fox Chase Cancer Center, 333 Cottman Avenue, Philadelphia, PA, 19111, USA.
Aldana VistaropCancer Epigenetics Institute, Nuclear Dynamics and Cancer Program, Fox Chase Cancer Center, Philadelphia, PA, 19111, USA.
Peter A McCueDepartment of Pathology, Fox Chase Cancer Center, 333 Cottman Avenue, Philadelphia, PA, 19111, USA.
Lu ChenCancer Epigenetics Institute, Nuclear Dynamics and Cancer Program, Fox Chase Cancer Center, Philadelphia, PA, 19111, USA.
Douglas B FliederDepartment of Pathology, Fox Chase Cancer Center, 333 Cottman Avenue, Philadelphia, PA, 19111, USA.

Funding

NIH Office of the Director GM150538
6 · The paper itself

Abstract

Adenoid cystic carcinoma (ACC) is the second most common malignancy of salivary glands with a poor long-term prognosis. The presence of mutually exclusive t(6;9)/MYB::NFIB and t(8;9)/MYBL1::NFIB chromosomal translocations has been used as diagnostic markers for ACC. In this study, we report a non-MYB/MYBL1 fusion gene NFIB::PHACTR2 in a palate ACC of a 66-year-old male. The excised 1.7 cm partially encapsulated tumor featured focal invasion into the adjacent mucinous minor salivary glands. By light microscopy, the tumor showed cribriform and tubular patterns with obvious perineural and intraneural invasion. The findings remind us that salivary gland tumors without MYB/MYBL1 fusion genes could still be ACC if they have a rearrangement involving genes adjacent to MYB/MYBL1 genes.

Indexed as

Biomarkers, TumorCarcinoma, Adenoid CysticNFI Transcription FactorsOncogene Proteins, FusionPalatal NeoplasmsSalivary Gland NeoplasmsAgedGene FusionHumansMaleProto-Oncogene ProteinsTrans-ActivatorsBiomarkers, TumorMYBL1 protein, humanNFIB protein, humanNFI Transcription FactorsOncogene Proteins, FusionProto-Oncogene ProteinsTrans-ActivatorsAdenoid cystic carcinomaFusionNFIBPHACTR2RearrangementTranslocation

Identifiers

PMID40257526

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.