ArticleJournal of cosmetic dermatology2025
Management of Delayed Complications of Hyaluronic Acid Fillers: Case Series From the Middle East.
Article in Journal of cosmetic dermatology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
4 citing papers in PubMed.
- Ultrasound imaging in aesthetic medicine: safety and precision in injectable procedures.Journal of ultrasound · 2026Review
- Single-Session High-Dose Hyaluronidase for Managing Periorbital Hyaluronic Acid Filler Complications.Aesthetic plastic surgery · 2026Article
- Comparative Effects of Injectable Biostimulatory Agents (Calcium Hydroxyapatite, New Cellular Treatment Factor, VAMP, and Human Exosomes) and Their Combination on Skin Regeneration.Aesthetic surgery journal. Open forum · 2026Article
- Hyaluronidase Use in Aesthetic Medicine: Formulations, Safety, and Clinical Practice.Journal of clinical medicine · 2025Review
Corrections and comments
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Authors and funding
2 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundHyaluronic acid (HA) dermal fillers are primarily utilized for restoring volume loss and for the correction of wrinkles and folds. While HA injections are generally considered safe, undesirable and serious complications have been on the rise due to the increased frequency of these procedures. Late-onset complications involve filler migration, foreign body granuloma reactions, delayed hypersensitivity reactions, and infections, among others. AIMS/
objectivesRaising awareness about late complications associated with HA filler injections and highlighting proper management strategies.
methodsWe hereby present three patients who experienced distinct forms of delayed reactions to HA fillers, provide a systematic approach to their evaluation, and outline effective treatment strategies to ensure optimal patient outcomes. Written informed consent was obtained from the patients for publication of the details of their medical cases and any accompanying images.
resultsDelayed complications to HA fillers include erythema, edema, inflammation, nodules, and infections. These late-onset reactions present weeks to months post-injection and may be influenced by immune responses, filler properties, and procedural factors. Ultrasound imaging is a valuable tool in diagnosing and managing these complications, guiding treatments such as hyaluronidase and corticosteroid injections. Preventive measures, including aseptic techniques, patient screening, and proper injector training, help in reducing risks and optimizing patient outcomes.
conclusionHA filler injections remain among the most popular cosmetic procedures, generally offering safe outcomes when performed by skilled professionals. Complications may still occur and require prompt recognition and management. This article highlights the importance of imaging in diagnosing non-ischemic complications and provides practical recommendations for managing delayed HA filler reactions. Ensuring patient safety relies on proper training, adherence to aseptic techniques, and careful patient and product selection.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.