Evidence map›Paper›PMID 40257409›Full record

ArticleEuropean journal of immunology2025

Pamidronate-Induced Clinical Remission in Chronic Non-bacterial Osteomyelitis Is Associated with Reduced Vγ9Vδ2 T-Cell Receptor Expression.

Lily Watson, Athimalaipet V Ramanan, Elizabeth Oliver, Francisca Segers, Gareth W Jones, Christine Chew, Anu Goenka

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in European journal of immunology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Review
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Lily WatsonBristol Medical School, University of Bristol, Bristol, UK.
Athimalaipet V RamananPaediatric Rheumatology, Bristol Royal Hospital for Children, Bristol, UK.
Elizabeth OliverBristol Medical School, University of Bristol, Bristol, UK.
Francisca SegersSchool of Biological Sciences, University of Bristol, Bristol, UK.
Gareth W JonesBristol Medical School, University of Bristol, Bristol, UK.
Christine ChewBristol Medical School, University of Bristol, Bristol, UK.ORCID 0000-0003-3598-6669
Anu GoenkaBristol Medical School, University of Bristol, Bristol, UK.ORCID 0000-0002-8152-2155

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

In children with chronic non-bacterial osteomyelitis, clinical and transcriptional changes in peripheral blood were examined after pamidronate treatment. Clinically effective treatment with pamidronate was associated with reduced expression of two genes (TRDV2 and TRGV9) that encode the subunits of the Vγ9Vδ2 T-cell receptor.

Indexed as

DiphosphonatesOsteomyelitisReceptors, Antigen, T-Cell, gamma-deltaAdolescentChildChild, PreschoolChronic DiseaseFemaleHumansMalePamidronateDiphosphonatesPamidronateReceptors, Antigen, T-Cell, gamma-deltachronic non‐bacterial osteomyelitisgamma‐delta T cellspamidronateRNA sequencing

Identifiers

PMID40257409
PMCPMC12010949

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.