ArticleOtolaryngology--head and neck surgery : official journal of American Academy of Otolaryngology-Head and Neck Surgery2025
Elective Neck Dissection in cT1-4 N0M0 Head and Neck Spindle Cell Carcinoma.
Article in Otolaryngology--head and neck surgery : official journal of American Academy of Otolaryngology-Head and Neck Surgery, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
objectiveTo investigate the survival benefit of elective neck dissection (END) over neck observation in surgically resected cT1-4 N0M0 head and neck spindle cell carcinoma (HNSpCC). STUDY
designRetrospective cohort study.
settingThe 2006 to 2018 hospital-based National Cancer Database (NCDB).
methodsPatients with surgically resected cT1-4 N0M0 HNSpCC were selected. Linear, binary logistic, Kaplan-Meier, and Cox proportional hazards regression models were implemented.
resultsOf 815 patients satisfying inclusion criteria, a high proportion were male (72.4%) and white (86.0%) with disease of the larynx (43.8%) classified as high grade (87.7%) and cT1-2 (74.8%). In total, 235 (28.8%) patients underwent END. END utilization between 2006 and 2018 increased for cT1-2 disease (4.0% vs 30.5%, R
conclusionEND is performed in a high proportion (30%) of patients with cN0M0 HNSpCC but is not associated with higher OS. The rate of ONM approaching 25% and the association between ONM and worse OS, however, justify consideration of END in HNSpCC. LEVEL OF EVIDENCE: 4:
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