Evidence map›Paper›PMID 40257298›Full record

ReviewTurkish journal of haematology : official journal of Turkish Society of Haematology2025

The Advancing Landscape of Paroxysmal Nocturnal Hemoglobinuria Treatment

Cameron Perry, Xinyu Von Buttlar, Swapna Thota

Abstract readReview
In one paragraph

Review in Turkish journal of haematology : official journal of Turkish Society of Haematology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Review
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Cameron PerryUniversity of Tennessee Health Science Center College of Medicine, Department of Hematology and Oncology, Memphis, United StatesORCID 0009-0001-8093-5548
Xinyu Von ButtlarUniversity of Tennessee Health Science Center, Department of Internal Medicine, Division of Hematology and Oncology, Memphis, United StatesORCID 0000-0001-6131-8555
Swapna ThotaUniversity of Tennessee Health Science Center, Department of Internal Medicine, Division of Hematology and Oncology, Memphis, United StatesORCID 0000-0002-4216-1414

Funding

PROFESSIONAL ONCOLOGY EDUCATION PROGRAMR25CA023944 · NCI · ST. JUDE CHILDREN'S RESEARCH HOSPITAL · PI SUZANNE A. GRONEMEYER · 1986 to 2026
$8.3M
WT1 as an oncogene and therapeutic target in anaplastic Wilms tumorK08CA255569 · NCI · ST. JUDE CHILDREN'S RESEARCH HOSPITAL · PI MURPHY, ANDREW J · 2021 to 2025
$1.2M
A Mouse Model for Emotional Disorder Caused by Mild Traumatic Brain InjuryR21NS081370 · NINDS · UNIVERSITY OF TENNESSEE HEALTH SCI CTR · PI REINER, ANTON J. · 2013 to 2014
$410k
NCI NIH HHS K08 CA255569NCI NIH HHS R25 CA023944NINDS NIH HHS R21 NS081370
6 · The paper itself

Abstract

Paroxysmal nocturnal hemoglobinuria (PNH) is a rare chronic bone marrow failure condition characterized by complement-mediated hemolytic anemia and thrombosis. While its initial clinical description occurred in 1882, somatic mutations in

Indexed as

Complement Inactivating AgentsHemoglobinuria, ParoxysmalAntibodies, Monoclonal, HumanizedHumansAntibodies, Monoclonal, HumanizedComplement Inactivating AgentseculizumabravulizumabAplastic anemiaNovel complement inhibitorsParoxysmal nocturnal hemoglobinuria

Identifiers

PMID40257298
PMCPMC12099479

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.