Evidence map›Paper›PMID 40257286›Full record

ReviewNanomedicine (London, England)2025

(Re)evolution in nanoparticles-loaded microneedle delivery systems: are we getting closer to a clinical translation?

Antonio José Guillot, Ana Melero

Abstract readReview
In one paragraph

Review in Nanomedicine (London, England), 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors.

Antonio José GuillotDepartment of Pharmacy and Pharmaceutical Technology and Parasitology, University of Valencia, Valencia, Spain.ORCID 0000-0001-8012-326X
Ana MeleroDepartment of Pharmacy and Pharmaceutical Technology and Parasitology, University of Valencia, Valencia, Spain.ORCID 0000-0003-0126-414X

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The deposition of drug-loaded nanoparticles within the skin structure has been a challenge due to the inexorable skin barrier function. Unless specific nanoparticles like liposomes and lipid-based related vesicles, most nanoparticles cannot penetrate the epidermal layers by themselves. This is the reason why microneedle-based systems are nowadays the most straightforward systems in skin research. They can greatly bypass the

Indexed as

Drug Delivery SystemsNanoparticlesNeedlesAdministration, CutaneousAnimalsHumansMicroinjectionsPrinting, Three-DimensionalSkinSkin AbsorptionTranslational Research, Biomedical3D-printingclinical translationMicroneedle-based systemsmicroneedle regulatory frameworkmicroneedles and nanoparticles combination

Identifiers

PMID40257286
PMCPMC12068352

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.