ArticleCurrent neuropharmacology2025
Altered GABAergic Homeostasis in the Striatum of Dopamine Transporter Knockout Rats.
Article in Current neuropharmacology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
2 citing papers in PubMed.
- Assessment of Addictive Behavior in Rats with Partial Knockout of the Dopamine Transporter Gene.International journal of molecular sciences · 2026Article
- The Aqueous Extract of De-Oiled Lavender Exerts Hypnotic Effect Through the GABAergic System in Mice.Chemistry & biodiversity · 2026Article
Corrections and comments
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Authors and funding
7 authors.
Funding
Abstract
backgroundIt is now widely established that dopamine, despite its nature as a slowacting biogenic monoamine, modulates fast neurotransmitters such as GABA. However, the mechanism through which this occurs still needs to be fully elucidated. The dopamine transporter (DAT) is the primary regulator of dopamine homeostasis, controlling extracellular levels of dopamine as well as its storage in vesicles.
methodsHere, we took advantage of the availability of dopamine transporter knockout (DAT
resultsWe found a widespread down-regulation of GABAergic markers in the striatum of DAT
conclusionTaken together, such changes paint a picture showing a compromised integrity of the striatal GABAergic system under conditions of functional hyperdopaminergia, which may be of interest for several disorders of the central nervous system.
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