ArticleEuropean journal of neurology2025
Change in Structural Connectivity Following Stereotactic Thermocoagulation in Mesial Temporal Lobe Epilepsy Patients.
Article in European journal of neurology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
1 citing paper in PubMed.
- Seizure Freedom Despite Piriform Cortex Sparing: Structural Connectivity Remodeling After SEEG-Guided Mesial Temporal RFTC.European journal of neurology · 2026Article
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Authors and funding
11 authors.
Funding
Abstract
aimsTo examine the association between postoperative lesions in distinct ROIs of the brain and the impact that their ablation would have on the structural and functional brain connectivity relative to outcomes.
methodsWe retrospectively reviewed 21 patients with refractory unilateral MTLE. The percentage of each ablated gray matter region of interest (ROIs) was calculated, using a voxel-by-voxel comparison. The percentage of the affected fibers was calculated by assessing the neuronal change reflected by a decrease in anisotropy in the repeat scans (i.e., pre and postoperative). Graph theory analysis was used to investigate the change in the pre and postoperative structural and functional networks between the seizure-free and non-seizure-free groups.
resultsFifteen patients (71.42%) were seizure-free and six (28.57%) were non-seizure-free at a 12 to 48 months (23.80 ± 8.93) follow-up. Four patients (19.04%) reported memory decline following RFTC. The seizure-free group showed a larger ablation volume of both the amygdala (p = 0.024) and rhinal cortex (p = 0.035), and an alteration in structural connectivity networks metrics (p < 0.05) compared to the non-seizure-free group.
conclusionsOur study shows that a higher ablation of both the amygdala and rhinal cortex led to improved structural connectivity and was associated with better outcomes. Our results provide insight into some essential elements of brain connectivity networks in MTLE and might contribute to the generation of novel evidence that could improve SEEG-guided RFTC interventions in MTLE patients.
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