ArticleCancer management and research2025
Impact of the Timing of Protective Stoma Reversal on Survival in Rectal Cancer Patients Undergoing Postoperative Adjuvant Chemotherapy: A Retrospective Single Center Study.
Article in Cancer management and research, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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1 citing paper in PubMed.
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6 authors.
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Abstract
Background: Postoperative adjuvant chemotherapy used in patients with stage II/III rectal cancer, is usually administered for 3 to 6 months. However, the optimal timing of protective stoma reversal remains controversial. This study aimed to investigate the effect of stoma closure before or after adjuvant chemotherapy on survival and stoma-related complications. Methods: A retrospective analysis was conducted on 144 patients who underwent radical rectal cancer surgery, prophylactic ileostomy and adjuvant chemotherapy from June 2018 to June 2021. 104 had their stoma reversal before adjuvant chemotherapy completion (Before group) and 40 after adjuvant chemotherapy completion (After group). Results: There were no significant differences between the groups regarding demographics, clinical characteristics, perioperative complications, OS, or DFS. Pathologic T-stage [HR = 2.620 (1.291-5.320), Conclusion: In high-risk stage III patients, delayed stoma reversal after adjuvant chemotherapy may improve survival, but it may also lead to more stoma-related complications.
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