Evidence map›Paper›PMID 40256729›Full record

ArticlePeerJ2025

CDCP1 knockdown suppresses PDGFRβ/AKT pathway-mediated vascular smooth muscle cell proliferation by inhibiting PDGFRβ endocytosis.

Xin Ji, Xin Wang, Qianqian Dong, Wanqiu Li, Ning Zhou, Xiaole Yue, Dandan Zhao, Xiaolong Yang

Abstract read
In one paragraph

Article in PeerJ, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Review
  2. Review
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Xin Ji *Hebei Key Laboratory of Animal Physiology, Biochemistry and Molecular Biology, Hebei Collaborative Innovation Center for Eco-Environment, Ministry of Education Key Laboratory of Molecular and Cellular Biology, College of Life Sciences, Hebei Normal University, Shijiazhuang, Hebei Province, China.
Xin Wang *Department of Clinical Laboratory, The Second Hospital of Hebei Medical University, Shijiazhuang, Hebei Province, China.
Qianqian DongDepartment of Clinical Laboratory, The Second Hospital of Hebei Medical University, Shijiazhuang, Hebei Province, China.
Wanqiu LiDepartment of Clinical Laboratory, The Second Hospital of Hebei Medical University, Shijiazhuang, Hebei Province, China.
Ning ZhouDepartment of Clinical Laboratory, Southern University of Science and Technology Hospital, Shenzhen, Guangdong Province, China.
Xiaole YueDepartment of Clinical Laboratory, The Second Hospital of Hebei Medical University, Shijiazhuang, Hebei Province, China.
Dandan ZhaoDepartment of Clinical Laboratory, The Second Hospital of Hebei Medical University, Shijiazhuang, Hebei Province, China.
Xiaolong YangHebei Key Laboratory of Animal Physiology, Biochemistry and Molecular Biology, Hebei Collaborative Innovation Center for Eco-Environment, Ministry of Education Key Laboratory of Molecular and Cellular Biology, College of Life Sciences, Hebei Normal University, Shijiazhuang, Hebei Province, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

CUB domain-containing protein 1 (CDCP1) is a type of cell surface glycoprotein that has been identified as being capable of regulating cell anchorage, migration, proliferation, and differentiation. However, the contributions of CDCP1 in intimal hyperplasia, specifically regarding the proliferation and migration of vascular smooth muscle cells (VSMC), are unclear. In this study, we analyzed CDCP1 expression on intimal hyperplasia through a focal carotid stenosis model

Indexed as

Antigens, CDCell Adhesion MoleculesCell ProliferationEndocytosisMuscle, Smooth, VascularMyocytes, Smooth MuscleProto-Oncogene Proteins c-aktReceptor, Platelet-Derived Growth Factor betaAnimalsBecaplerminCell MovementCells, CulturedGene Knockdown TechniquesMaleMiceMice, Inbred C57BLAntigens, CDBecaplerminCell Adhesion MoleculesProto-Oncogene Proteins c-aktReceptor, Platelet-Derived Growth Factor betaAKT signalingCDCP1ClathrinEndocytosisIntimal hyperplasiaPDGFRβ

Identifiers

PMID40256729
PMCPMC12007496

What OpenQuestion holds

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LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.