ArticleJournal of conservative dentistry and endodontics2025
Enhancing adhesive performance with N, N, N', N'-tetrakis (2-pyridyl methyl) ethylenediamine matrix metalloproteinase inhibitors: A comprehensive study of degree of conversion, microleakage, and micro-tensile bond strength in dental adhesives.
Article in Journal of conservative dentistry and endodontics, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
What it found
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Who cites it
2 citing papers in PubMed.
- Comparative evaluation of the resin-dentin interface using different matrix metalloproteinase inhibitors: A confocal laser scanning microscopic study.Journal of conservative dentistry and endodontics · 2026Article
- Influence of dentin extrafibrillar collagen demineralization on resin-dentin bond durability - AnJournal of conservative dentistry and endodontics · 2025Article
Corrections and comments
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Authors and funding
5 authors.
Funding
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Abstract
Aim: Matrix metalloproteinases (MMPs) play a significant role in the degradation of dentin collagen within hybrid layers, affecting the longevity of resin-bonded restorations. The incorporation of MMP inhibitors into dental adhesives has been explored to address this issue. This study aimed to assess the impact of the MMP inhibitor, N, N, N', N'-Tetrakis (2-pyridyl methyl) ethylenediamine (TPEN), on key adhesive properties, including the degree of conversion (DC), microleakage, and micro-tensile bond strength, shedding light on their potential in enhancing bond durability. Subjects and Methods: Microleakage evaluations were conducted on 24 premolar specimens, while micro-tensile bond strength measurements were performed on the buccal surface of dentin samples. The DC was determined using Fourier Transform Infrared spectroscopy (FTIR) spectroscopy. Results: The findings revealed no significant difference in DC between the adhesive with MMP inhibitors and the control group ( Conclusion: The results suggest that including TPEN can effectively enhance micro-tensile bond strength in dental adhesives without compromising DC or exacerbating microleakage. This highlights the potential of MMP inhibitors in improving bond durability in restorative dentistry.
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Registered trials
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