ArticleJournal of conservative dentistry and endodontics2025
Comparative evaluation of postoperative pain and healing following root canal obturation with calcium silicate and bioactive glass-based sealers to epoxy resin-based sealers: A systematic review and meta-analysis.
Article in Journal of conservative dentistry and endodontics, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT07307807 (Evaluation of Postoperative Pain and Lesion Healing in Periapical Lesion-Affected Teeth Obturated With Different Root Canal Sealers), which is not on this map. Cited by 12 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Evaluation of Postoperative Pain and Lesion Healing in Periapical Lesion-Affected Teeth Obturated With Different Root Canal Sealers: Prospective Study
Who cites it
12 citing papers in PubMed.
- Endodontic treatment outcomes in apical periodontitis cases by the lateral condensation versus warm vertical compaction techniques: a one-year follow-up study.BMC oral health · 2026Trial
- Bioceramic versus conventional endodontic sealers: An umbrella review.Journal of conservative dentistry and endodontics · 2026Review
- Post-Operative Pain After Endodontic Instrumentation, Irrigation and Obturation: An Umbrella Review of Systematic Reviews Published from 2016 to 2025.Journal of clinical medicine · 2026Review
- Fabrication and characterization of a bioactive glass and tricalcium silicate incorporated resin-based root canal sealer.Journal of conservative dentistry and endodontics · 2026Article
- Cytotoxicity of Root Canal Sealers and Potential Clinical Implications: A Comprehensive Systematic Review of In Vitro Studies.Journal of clinical medicine · 2026Review
- Influence of moist dentin and dry dentin on sealing ability of bioceramic sealer using confocal laser scanning microscope: AnJournal of conservative dentistry and endodontics · 2026Article
- Assessment of postoperative pain after the use of calcium silicate bioceramic sealer - BioRoot RCS: A double-blinded randomized clinical trial.Journal of conservative dentistry and endodontics · 2026Article
- Clinical implications of apically extruded resin-based sealers: A long-term observation.Journal of conservative dentistry and endodontics · 2025Article
- Comparative evaluation of pushout bond strength of three different sealers: AnJournal of conservative dentistry and endodontics · 2025Article
- Change in serum biomarker levels in patients of apical periodontitis after root canal treatment using two different root canal sealers: A randomized controlled trial.Journal of conservative dentistry and endodontics · 2025Article
- Evidence synthesis of postoperative pain with bioceramic vs. epoxy resin sealers: umbrella review of randomized trials within existing systematic reviews.Frontiers in dental medicine · 2025Review
- Clinical and radiographic success of single-cone bioceramic obturation versus traditional techniques: a systematic review and meta-analysis of randomized controlled trials.Journal of oral biology and craniofacial researchReview
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Aim: To compare the postoperative pain and healing following obturation with calcium silicate and bioactive glass-based sealers to epoxy resin sealers. Materials and Methods: A systematic search (2018-2024) was conducted using PubMed, Cochrane, and Google Scholar, following the Preferred Reporting Items for Systematic Reviews and Meta-analyses guidelines (PRISMA). Risk of bias (RoB) was assessed using Cochrane RoB 2 tool and quality was evaluated using GRADE. Twenty-three studies were included for qualitative analysis and 11 for quantitative analysis, including meta-analysis for bioactive glass and epoxy resin-based sealers. Results: Meta-analysis revealed no significant difference in pain occurrence between groups at 24 h, 48 h, and 7 days. Similarly, for bioactive glass sealer, no significant difference in pain occurrence was observed at 24 h, 48 h, and 7 days. Conclusion: Calcium-silicate-based sealers showed comparable and satisfactory results to epoxy resin sealers regarding postoperative pain incidence and intensity. In addition, they facilitated improved healing of periapical tissues. Notably, bioactive glass-based sealer also demonstrated exceptional properties, offering enhanced benefits.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.