ArticleClinical parkinsonism & related disorders2025
How to treat orthostatic tremor - Cohort study and systematic review.
Article in Clinical parkinsonism & related disorders, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
3 citing papers in PubMed.
- Treatment Continuation and Long-Term Outcomes of Perampanel in Primary Orthostatic Tremor; A Cohort Study.Movement disorders clinical practice · 2026Observational
- Article
- Tremor: Clinical Frameworks, Network Dysfunction and Therapeutics.Brain sciences · 2025Review
Corrections and comments
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Authors and funding
5 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Introduction: Orthostatic tremor (OT) is a highly disabling condition. Effectiveness of treatments is largely unverified and no treatment guideline exists. The objective of this study is to evaluate the efficacy and adverse effects of treatments used for OT. Methods: Patients from our online OT-registry were compared to findings from a systematic search in PUBMED. The search included original articles describing clinical features in human primary OT (electromyography peak frequency ≥ 13 Hz), in English or Dutch, and published after 1985. Outcome measures were prescribed treatments and their efficacy (percentage of patients per treatment with a reduction of tremor symptoms) and adverse effects. Results: A total of 78 primary OT patients in the Netherlands and 613 OT patients from 74 articles, mostly case reports and cohort studies, were included. In the cohort from the Netherlands, perampanel showed both the highest efficacy and adverse effects. In the literature, clonazepam showed the highest efficacy, while data on adverse effects was lacking. Overall, pharmacological treatments were reported often to be insufficient. Bilateral deep brain stimulation (DBS) was reported to be effective in the majority of patients, without a higher prevalence of adverse effects. Conclusion: Pharmacological treatment is sufficient in some patients, although overall efficacy is limited and often accompanied by adverse effects. Perampanel and clonazepam are first choice treatments. Surgical interventions seem suitable alternatives for medication resistant patients, although this is based on small studies. Future studies should use diagnostic criteria, standardized outcome scales and good study designs, to increase reliability of findings and comparability.
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