ArticleACS omega2025
Preclinical Safety Assessment and Serum Lipid Profiles of Wister Rats Following Acute and Subchronic Exposure to Water-Soluble Curcuminoid-Rich Extracts.
Article in ACS omega, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
4 citing papers in PubMed.
- Effects of lawsone and lawsone methyl ether on cyclooxygenase activity, redox balance, and organ-specific toxicity: An integrated computational and experimental study.Toxicology reports · 2026Article
- COMolecules (Basel, Switzerland) · 2026Article
- Mechanistic Insights into Dihydromyricetin: Redox Modulation and Kinase-Mediated Control of Disease Pathogenesis.International journal of molecular sciences · 2026Review
- Article
Corrections and comments
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Authors and funding
4 authors.
Funding
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Abstract
The present study aimed to establish water-soluble curcuminoid-rich extracts and assess their acute and subchronic toxicities, following the OECD guidelines. Water-soluble curcuminoid-rich extracts, namely, CRE-Ter [ternary complex of curcuminoid-rich extract (CRE), hydroxypropyl-β-cyclodextrin, and polyvinylpyrrolidone K30] and CRE-SD (CRE in a solid dispersion form with polyvinylpyrrolidone K30) were produced via green technology, and their curcuminoid content was subsequently quantified using a high-performance liquid chromatographic (HPLC) method. CRE-Ter and CRE-SD contained 17.8% (w/w) total curcuminoids (12.7% (w/w) of curcumin, 3.2% (w/w) of demethoxycurcumin, and 1.9% (w/w) of bisdemethoxycurcumin) and 7.5% (w/w) total curcuminoids (5.2% (w/w) of curcumin, 1.4% (w/w) of demethoxycurcumin, and 0.9% (w/w) of bisdemethoxycurcumin), respectively. The acute and subchronic toxicities of the extracts were investigated in both male and female rats. The limit test of acute toxicity revealed that the oral LD
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Registered trials
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