Evidence map›Paper›PMID 40256536›Full record

ArticleACS omega2025

Preparative Coupled Enzymatic Synthesis of L-Homophenylalanine and 2-Hydroxy-5-oxoproline with Direct In Situ Product Crystallization and Cyclization.

Sven Tiedemann, Annabel Stang, Simon Last, Thierry Gefflaut, Jan von Langermann

Abstract read
In one paragraph

Article in ACS omega, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Sven TiedemannOtto von Guericke University Magdeburg, Institute of Chemistry, Biocatalysis Group, Universitätsplatz 2, 39106 Magdeburg, Germany.
Annabel StangOtto von Guericke University Magdeburg, Institute of Chemistry, Biocatalysis Group, Universitätsplatz 2, 39106 Magdeburg, Germany.
Simon LastOtto von Guericke University Magdeburg, Institute of Chemistry, Biocatalysis Group, Universitätsplatz 2, 39106 Magdeburg, Germany.
Thierry GefflautUniversité Clermont Auvergne, Institut de Chimie de Clermont-Ferrand, 24 avenue des Landais, 63178 Aubiere Cedex, France.ORCID https://orcid.org/0000-0002-4411-8233
Jan von LangermannOtto von Guericke University Magdeburg, Institute of Chemistry, Biocatalysis Group, Universitätsplatz 2, 39106 Magdeburg, Germany.ORCID https://orcid.org/0000-0001-9302-9803

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

A continuous in situ crystallization concept is presented for the coupled preparative synthesis of L-homophenylalanine and 2-hydroxy-5-oxoproline (a cyclized form of α-ketoglutarate) using the α-transaminase from

Identifiers

PMID40256536
PMCPMC12004150

What OpenQuestion holds

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LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.