ArticleAdvanced synthesis & catalysis2025
Phosphorus Fluoride Exchange (PFEx) Click Chemistry: 2-Substituted-alkynyl-1-cyclotriphosphazene (SACP) Hubs for Diversity Oriented Clicking.
Article in Advanced synthesis & catalysis, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.
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Who cites it
4 citing papers in PubMed.
- The evolution of click chemistry: from classical reactions to next-generation platforms.RSC advances · 2026Review
- Click chemistry for natural product-inspired covalent drug discovery.Drug discovery today · 2025Review
- Disubstituted Meldrum's Acid: Another Scaffold with SuFEx-like Reactivity.Molecules (Basel, Switzerland) · 2025Article
- Diversity Oriented Clicking for Modular Synthesis.Nature reviews. Methods primers · 2025Article
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Authors and funding
10 authors.
Funding
Abstract
Phosphorus Fluoride Exchange (PFEx) is a new click chemistry technology that hinges on the creation of innovative hubs to unlock its potential and broaden its applications. In this study, we outline some guiding principles for PFEx hub development and validate these principles by developing a new hub, 2-substituted-alkynyl-1-cyclotriphosphazenes (SACPs). These SACPs serve as versatile PFEx hubs with stable functionality and orthogonal reactivity, exemplifying their utility within the Diversity Oriented Clicking (DOC) framework. We demonstrate that SACPs interact with various 1,3-dipoles, enabling the synthesis of phosphorus-rich compounds through sequential cycloaddition and PFEx reactions, thus pioneering new synthetic routes for wide application of click chemistry.
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Registered trials
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