Evidence map›Paper›PMID 40256398›Full record

ArticleFrontiers in pediatrics2025

Severe neonatal cholestasis in

Chiara Gagliano, Olga Burattini, Luigi Paradisi, Sarah Recchione, Lucia Santoro, Laura Caponi, Annamaria Ciaschini, Maria Elena Lionetti, Simona Gatti

Abstract readCase Reports
PubMed Full text at PMC Publisher
In one paragraph

Article in Frontiers in pediatrics, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Chiara GaglianoDepartment of Pediatrics, University Polytechnic of Marche, Ancona, Italy.
Olga BurattiniDepartment of Pediatrics, University Polytechnic of Marche, Ancona, Italy.
Luigi ParadisiDepartment of Pediatrics, University Polytechnic of Marche, Ancona, Italy.
Sarah RecchioneDepartment of Pediatrics, University Polytechnic of Marche, Ancona, Italy.
Lucia SantoroDepartment of Pediatrics, University Polytechnic of Marche, Ancona, Italy.
Laura CaponiDepartment of Pediatrics, University Polytechnic of Marche, Ancona, Italy.
Annamaria CiaschiniLaboratory of Medical Genetics, Azienda Ospedaliero Universitaria Delle Marche, Ancona, Italy.
Maria Elena LionettiDepartment of Pediatrics, University Polytechnic of Marche, Ancona, Italy.
Simona GattiDepartment of Pediatrics, University Polytechnic of Marche, Ancona, Italy.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Neonatal cholestasis can be caused by several conditions, with biliary atresia being the major cause. Genetic and endocrinological etiologies represent other possibilities, with most of them requiring a rapid diagnosis and a specific treatment. We describe a neonatal case of severe cholestasis with low gamma glutamyl transferase in a child presenting with multiple abnormalities, including pituitary stalk interruption syndrome and consequent hypopituitarism. The cholestasis was rapidly resolved with hormone therapy. Genetic analysis showed a

Indexed as

17q12 deletioncongenital hypopituitarismHNF1βliver diseaseneonatal cholestasispituitary stalk interruption syndrome

Identifiers

PMID40256398
PMCPMC12006077

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.