Evidence map›Paper›PMID 40256221›Full record

ReviewBioImpacts : BI2025

A systematic review on the use of phytotherapy in managing clinical depression.

Sutude Fazilat, Fateme Tahmasbi, Mohammad Reza Mirzaei, Sarvin Sanaie, Zahra Yousefi, Solmaz Asnaashari, Shadi Yaqoubi, Ahad Banagozar Mohammadi, Mostafa Araj-Khodaei

Abstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in BioImpacts : BI, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Involvement of Serotonergic and Dopaminergic Systems inPharmaceuticals (Basel, Switzerland) · 2026
    Article
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Sutude FazilatResearch Center for Integrative Medicine in Aging, Aging Research Institute, Tabriz University of Medical Sciences, Tabriz, Iran.ORCID https://orcid.org/0009-0004-4698-8357
Fateme TahmasbiSocial Determinants of Health Research Center, Health Management and Safety Promotion Research Institute, Tabriz University of Medical Sciences, Tabriz, Iran.
Mohammad Reza MirzaeiDepartment of Persian Medicine, Faculty of Traditional Medicine, Tabriz University of Medical Sciences, Tabriz, Iran.
Sarvin SanaieNeurosciences Research Center, Aging Research Institute, Tabriz University of Medical Sciences, Tabriz, Iran.
Zahra YousefiResearch Center of Psychiatry and Behavioral Sciences, Aging Research Institute, Tabriz University of Medical Sciences, Tabriz, Iran.
Solmaz AsnaashariBiotechnology Research Center, Tabriz University of Medical Sciences, Tabriz, Iran.
Shadi YaqoubiFaculty of pharmacy, Tabriz University of Medical Sciences, Tabriz, Iran.
Ahad Banagozar MohammadiDepartment of Persian Medicine, Faculty of Traditional Medicine, Tabriz University of Medical Sciences, Tabriz, Iran.ORCID https://orcid.org/0000-0002-2786-340X
Mostafa Araj-KhodaeiNeurosciences Research Center, Aging Research Institute, Tabriz University of Medical Sciences, Tabriz, Iran.ORCID https://orcid.org/0000-0002-2590-8467

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Introduction: The use of medicinal plants in the management of depression, also known as phytotherapy or herbal medicine for depression, is an area of growing interest in the field of mental health and complementary medicine. Methods: This study used a systematic assessment of pertinent literature to assess the effectiveness of medicinal herbs in treating mild to severe depression. A comprehensive literature search was conducted to identify randomized controlled trials (RCTs) that reported data on the intervention, control group, adverse events, outcome measurements, and main findings. A summary and analysis were done on the included research data. Results: We included 23 RCTs investigating the efficacy of herbal medicines, including Conclusion: More investigation is required to fully understand the mechanisms of action, ideal dosage schedules, long-term effects, and relative efficacy of medicinal plants in depressive treatment.

Indexed as

DepressionDepressive disorderHerbal medicinePhytotherapySystematic review

Identifiers

PMID40256221
PMCPMC12008507

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.