One-pot hydrothermal synthesize and characterization of Au/Gd bimetallic nanostructure as potential contrast agents in CT and MR imaging.

Introduction: Multimodal contrast agents play an important role in early diagnosis of diseases and monitoring the treatment outcomes by increasing the accuracy and clarity of images. Methods: Herein, a one-step simple hydrothermal route is utilized to prepare the gadolinium-1,4 H Results: The spherical nano-sized Au decorated Gd bimetal nanostructures have an average diameter of 64 nm. The presence of both Au and Gd metals in the prepared nanostructure was confirmed using EDAX. The XRD pattern shows that, in the hydrothermal synthesis of two metals using a terephthalic acid linker, gold nanoclusters are decorated onto the gadolinium metal organic framework. The FTIR analysis confirmed the attachment of Gd to the carboxylate group of the organic linker. The bimetal nanostructure sample with a concentration of 40 mM showed similar X-ray attenuation to that of iodine at a concentration of 128 mM. At a magnetic field strength of 1.5 T, the longitudinal relaxivity value of the bimetal nanostructure was determined to be 13.635 mM Conclusion: The fabricated bimetal nanostructure exhibits dose-dependent positive contrast enhancement in both MR and CT imaging techniques, making it a promising candidate for use as a contrast agent in medical applications.