Evidence map›Paper›PMID 40256217›Full record

ReviewBioImpacts : BI2025

Overview of dendritic cells subsets and their involvement in immune-related pathological disease.

Mohsen Abbaszadeh, Bahar Naseri, Mohammad Taghizadeh-Teymorloei, Amirhossein Mardi, Mohammad Reza Javan, Javad Masoumi, Farid Ghorbaninezhad, Amirhossein Hatami-Sadr, Şengül Tural, Behzad Baradaran and 1 more

Abstract readReview
In one paragraph

Review in BioImpacts : BI, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

12 citing papers in PubMed.

  1. Review
  2. Article
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  9. Spatial patterns and prognostic relevance of CD1aCancer immunology, immunotherapy : CII · 2025
    Article
  10. Article
  11. Review
  12. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Mohsen AbbaszadehMolecular Medicine Department, Faculty of advanced Medical Sciences, Tabriz University of Medical Sciences, Tabriz, Iran.ORCID https://orcid.org/0000-0002-6405-8688
Bahar NaseriImmunology Research Center, Tabriz University of Medical Sciences, Tabriz, Iran.
Mohammad Taghizadeh-TeymorloeiMolecular Medicine Department, Faculty of advanced Medical Sciences, Tabriz University of Medical Sciences, Tabriz, Iran.ORCID https://orcid.org/0000-0002-7783-8982
Amirhossein MardiImmunology Research Center, Tabriz University of Medical Sciences, Tabriz, Iran.
Mohammad Reza JavanDepartment of Immunology, Faculty of Medicine, Zabol University of Medical Sciences, Zabol, Iran.
Javad MasoumiImmunology Research Center, Tabriz University of Medical Sciences, Tabriz, Iran.
Farid GhorbaninezhadDepartment of Immunology, Faculty of Medicine, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
Amirhossein Hatami-SadrImmunology Research Center, Tabriz University of Medical Sciences, Tabriz, Iran.
Şengül TuralMayis University, Faculty of Medicine, Department of Medical Biology, Samsun, Turkey.
Behzad BaradaranImmunology Research Center, Tabriz University of Medical Sciences, Tabriz, Iran.
Mohammad Reza SadeghiMolecular Medicine Department, Faculty of advanced Medical Sciences, Tabriz University of Medical Sciences, Tabriz, Iran.ORCID https://orcid.org/0000-0002-7676-4168

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Dendritic cells (DCs) are specialized antigen-presenting cells (APCs) in linking innate and adaptive immune responses. In addition to presenting antigens to T cells, DCs must also provide co-stimulatory signals along with cytokines for T cells to induce an appropriate cellular immune response. Tolerance is also established and maintained by DCs under homeostatic circumstances. There is remarkable phenotypic heterogeneity in DCs, each with different functional flexibility and specific expression of various markers. The three primary categories of DCs comprise conventional DCs (cDCs), plasmacytoid DCs (pDCs), and monocyte-derived DCs (moDCs). Langerhans cells (LCs) are another type of DCs, which are found in the skin's epidermal layer. DCs may be positioned or triggered inappropriately as a result of dysregulation of DC. This phenomenon can cause an imbalance in immune responses and even immune-related pathological disorders, i.e., autoimmune diseases and malignancies. Herein, by reviewing the ontogeny, biology, characteristics, and function of DCs subsets in immune system, we discuss the contribution of these cells in the mentioned immune-related disorders.

Indexed as

Conventional DCsImmune-related disordersLangerhans cellsMonocyte-derived DCsPlasmacytoid DCs

Identifiers

PMID40256217
PMCPMC12008504

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.