Evidence map›Paper›PMID 40256213›Full record

ArticleBiological psychiatry global open science2025

Identifying Features of Resilience to Childhood Maltreatment in Resting-State Connectivity Data From Adults With and Without a History of Mood Disorder.

Mindy Westlund Schreiner, Leah R Thomas, Ha D H Le, Myah Pazdera, Daniel A Feldman, Brian Farstead, Katie L Bessette, Robert C Welsh, Sheila E Crowell, Erin A Kaufman and 2 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Biological psychiatry global open science, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Mindy Westlund SchreinerDepartment of Behavioral Health, Nationwide Children's Hospital, Columbus, Ohio.
Leah R ThomasDepartment of Psychiatry and Behavioral Health, The Ohio State University, Columbus, Ohio.
Ha D H LeDepartment of Pediatrics, University of California San Francisco, San Francisco, California.
Myah PazderaDepartment of Psychiatry, Huntsman Mental Health Institute, University of Utah, Salt Lake City, Utah.
Daniel A FeldmanDepartment of Psychiatry, Huntsman Mental Health Institute, University of Utah, Salt Lake City, Utah.
Brian FarsteadDepartment of Psychology, University of Southern Mississippi, Hattiesburg, Hattiesburg.
Katie L BessetteDepartment of Psychiatry and Biobehavioral Sciences and Semel Institute for Neuroscience and Human Behavior, University of California Los Angeles, Los Angeles, California.
Robert C WelshDepartment of Psychiatry and Biobehavioral Sciences and Semel Institute for Neuroscience and Human Behavior, University of California Los Angeles, Los Angeles, California.
Sheila E CrowellDepartment of Psychology, University of Oregon, Eugene, Oregon.
Erin A KaufmanDepartment of Psychiatry, Huntsman Mental Health Institute, University of Utah, Salt Lake City, Utah.
Heide KlumppDepartment of Psychiatry, University of Illinois at Chicago, Chicago, Illinois.
Scott A LangeneckerDepartment of Psychiatry and Behavioral Health, The Ohio State University, Columbus, Ohio.

Funding

Examining Mechanisms of Change in Adolescent Self-Inflicted InjuryK23MH135225 · NIMH · UTAH STATE HIGHER EDUCATION SYSTEM--UNIVERSITY OF UTAH · PI Erin Anne Kaufman · 2024 to 2026
$598k
NIMH NIH HHS K23 MH135225
6 · The paper itself

Abstract

Background: Childhood maltreatment (CM) is associated with negative mental health outcomes. Many studies conceptualize resilience as experiencing CM without developing psychopathology (primary resilience). However, some people may develop subsequent psychopathology but recover and demonstrate higher global functioning (secondary resilience). This study investigated the role of salience and emotion network (SEN) (including the amygdala, subgenual anterior cingulate cortex, and anterior insula) and cognitive control network (CCN) (including the dorsolateral prefrontal cortex, inferior parietal lobule, and thalamus) connectivity in primary and secondary resilience. Methods: We examined resting-state functional connectivity in 108 nonclinical control participants and 154 individuals with any mood disorder (AMD). We measured functioning and CM using the Global Assessment of Functioning (GAF) scale and the Childhood Trauma Questionnaire (CTQ), respectively. For primary resilience, we conducted whole-brain analyses of SEN and CCN regions to test for group × CTQ interactions. For secondary resilience, within-AMD group analyses tested for CTQ × GAF interactions. Results: Group × CTQ interactions revealed that control participants with higher levels of CM showed greater within-SEN and within-CCN connectivity than participants in the AMD group. In the AMD group, participants with higher levels of CM and functioning (secondary resilience) showed greater within-CCN connectivity while participants with higher levels of CM and lower functioning showed greater within-SEN connectivity. Conclusions: Greater SEN connectivity appears to play a key role in primary resilience, as observed in the control group, but only within the context of greater CCN connectivity. Future work should explore which cognitive control features are most beneficial and whether targeted interventions help foster resilience to recurrent psychopathology.

Indexed as

Child maltreatmentCognitive control networkMood disordersResilienceResting-state functional connectivitySalience and emotion network

Identifiers

PMID40256213
PMCPMC12008536

What OpenQuestion holds

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LicenceCC BY-NC-ND
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.