ArticleAlzheimer's & dementia (New York, N. Y.)
Effect of long-term treatment with memantine on mortality in patients with major cognitive disorders: A systematic review and meta-analysis.
Article in Alzheimer's & dementia (New York, N. Y.). The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers, 2 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
5 citing papers in PubMed, 2 syntheses or guidelines pooled it.
- Virtual reality-based cognitive training in mild cognitive impairment: a systematic review.Frontiers in aging neuroscience · 2026Pooled it
- Pharmacological treatment options for cognitive dysfunction induced by multiple sclerosis: a network meta-analysis.Frontiers in neurology · 2025Pooled it
- Effectiveness of acetylcholinesterase inhibitors and memantine in patients affected by severe dementia.GeroScience · 2026Article
- Neurotransmitter Systems in Alzheimer's Disease.Current issues in molecular biology · 2026Review
- Effect of long-term treatment with memantine on mortality in patients with major cognitive disorders: A systematic review and meta-analysis.Alzheimer's & dementia (New York, N. Y.)Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundDementia is responsible for a reduction in life expectancy, and the effect of memantine on mortality is still poorly understood. Our aim was to evaluate the effect of long-term treatment with memantine on all-cause mortality.
methodsIn this systematic review and meta-analysis, we searched five databases from their creation to June 2024.
resultsWe found 12 randomized trials (
conclusionOur results suggest that the use of memantine in patients with dementia may be associated with a reduction in all-cause mortality. Highlights: Dementia reduces patients' survival and the effect of long-term use of memantine on all-cause mortality is not well known.This systematic review and metanalysis included 19 studies including more than 24000 patients.We found that memantine in patients with dementia may be associated with a reduction in all-cause mortality.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.