ArticleJournal of family medicine and primary care2025
Unravelling interplay of serum MMP-7 and TGF- β in diabetic nephropathy - A study from a tertiary centre in eastern India.
Article in Journal of family medicine and primary care, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers, 1 of them a synthesis that pooled it.
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Who cites it
2 citing papers in PubMed, 1 synthesis or guideline pooled it.
- The diagnostic accuracy of MMP-7 for the diagnosis for biliary atresia- a systematic review and meta-analysis.BMC pediatrics · 2025Pooled it
- Unravelling the association between renal functions and anti thyroid peroxidase antibody levels in newly diagnosed cases of hypothyroidism in elderly.Frontiers in endocrinology · 2025Article
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Authors and funding
6 authors.
Funding
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Abstract
Background: Diabetic Nephropathy (DN) constitutes nearly half of cases of end stage renal disease. Despite decrease in kidney function, eGFR in the early stages may remain unaltered, making diagnosis difficult pointing towards need of more accurate biomarkers for early detection. Altered serum Matrix Metallo-Proteinase-7 (MMP-7) and transforming growth factor- β (TGF-β) has been noted independently in diabetic complications. The role of MMP-7 with TGF-β together has been highlighted in extracellular matrix remodelling in kidneys of diabetic rats. Interaction between MMP-7 with TGF- β in DN cases is scarce. Hence, the objective of present study is to evaluate role of serum MMP-7 and TGF-β in DN. Methods: This case control Study included 61 DN cases, 61 diabetes Mellitus controls and 61 healthy controls. After clinical evaluation routine biochemical parameters were estimated along with serum MMP-7 and TGF-β. They were analysed in relation to glycemia and eGFR along with correlation analysis. Results: Serum MMP-7 and TGF-β registered significant rise ( Conclusion: Serum MMP-7 along with TGF-β play significant role in the pathogenesis of DN. Prospective longitudinal study with future Genetic analysis for their expression is needed to establish their role in disease diagnosis and progression.
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