Evidence map›Paper›PMID 40256033›Full record

ArticleInternational journal of ophthalmology2025

OCT predictors of retinal atrophy in neovascular age-related macular degeneration treated with aflibercept.

Oscar M Gagliardi, Ludovico Alisi, Giacomo Visioli, Federica Dini, Giuseppe M Albanese, Stefano Scordari, Marco Marenco, Alessandro Lambiase, Rosalia Giustolisi

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Article in International journal of ophthalmology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
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1 · What the graph read from it

What it found

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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Review
  2. Tomographic phenotypes and conditional time to atrophic conversion in dry age-related macular degeneration among progressors: an interval-censored study.Graefe's archive for clinical and experimental ophthalmology = Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie · 2026
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4 · The record

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5 · Who and what money

Authors and funding

9 authors.

Oscar M GagliardiDepartment of Sense Organs, Sapienza University of Rome, Viale del Policlinico 155, Rome 00161, Italy.
Ludovico AlisiDepartment of Sense Organs, Sapienza University of Rome, Viale del Policlinico 155, Rome 00161, Italy.
Giacomo VisioliDepartment of Sense Organs, Sapienza University of Rome, Viale del Policlinico 155, Rome 00161, Italy.
Federica DiniDepartment of Neurosciences, Psychology, Drug Research and Child Health Eye Clinic, University of Florence, Viale Pieraccini 6, Florence 50139, Italy.
Giuseppe M AlbaneseDepartment of Sense Organs, Sapienza University of Rome, Viale del Policlinico 155, Rome 00161, Italy.
Stefano ScordariDepartment of Sense Organs, Sapienza University of Rome, Viale del Policlinico 155, Rome 00161, Italy.
Marco MarencoDepartment of Sense Organs, Sapienza University of Rome, Viale del Policlinico 155, Rome 00161, Italy.
Alessandro LambiaseDepartment of Sense Organs, Sapienza University of Rome, Viale del Policlinico 155, Rome 00161, Italy.
Rosalia GiustolisiDepartment of Sense Organs, Sapienza University of Rome, Viale del Policlinico 155, Rome 00161, Italy.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

aimTo identify optical coherence tomography (OCT) features present at the diagnosis of neovascular age-related macular degeneration (nAMD) that could predict retinal atrophy (RA) and visual performance in patients treated with intravitreal aflibercept.

methodsOCT data collected at the time of nAMD diagnosis (T0), after the first (T1) and third (T2) intravitreal aflibercept injection, and 5y post-diagnosis (T3) were analyzed. The study included 46 eyes from patients undergoing treatment. The association of OCT features with RA and visual acuity (VA) development over time were evaluated.

resultsPatients with RA at T3 exhibited worse VA (35.19±5.7

conclusionType 2 MNV, reduces ONL and CFT, and IRF presence at baseline may signal a higher risk of RA in treatment-naive nAMD patients, underscoring the importance of these OCT features in early risk assessment and management strategies.

Indexed as

long-term prognosisneovascular age-related macular degenerationOCT predictorsoptical coherence tomographyretinal atrophy

Identifiers

PMID40256033
PMCPMC11947533

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.