Protective effects of a mixture of multi-strain native Iranian probiotics on lead acetate-induced toxicity in the kidney of male rats: An integrated biochemical, molecular and histopathological study.

Mohsen Akbaribazm, Zahra Abdol Al Amir Mohammad Javad, Seyed Naser Alavi, Zahra Keshtmand

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Article in Avicenna journal of phytomedicine. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

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1citing papers in PubMed

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1 · What the graph read from it

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1 citing paper in PubMed.

Ameliorative effects ofAvicenna journal of phytomedicine · 2026
Article

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5 · Who and what money

Authors and funding

4 authors.

Mohsen AkbaribazmDepartment of Basic Medical Sciences, Khoy University of Medical Sciences, Khoy, Iran.

Zahra Abdol Al Amir Mohammad JavadDepartment of Biology, Science and Research Branch, Islamic Azad University, Tehran, Iran.

Seyed Naser AlaviDepartment of Biology, Central Tehran Branch, Islamic Azad University, Tehran, Iran.

Zahra KeshtmandDepartment of Biology, Central Tehran Branch, Islamic Azad University, Tehran, Iran.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Objective: In this study, the protective effects of native Iranian probiotics ( Materials and Methods: Twenty-one male Wistar rats were divided into three groups (n=7/group), including controls, PbAc recipient (10 mg/kg) and PbAc recipient (10 mg/kg) + probiotic mixture (10 Results: PbAc increased serum concentrations of Cr, sodium, and urea, and decreased total protein and potassium, while it enhanced interleukine-6 (IL-6) and tumor necrosis factor -α (TNF- α) gene expression in kidney tissue compared to the control group. Probiotic mixture decreased Cr, BUN, and malondialdehyde and increased activity of catalase and superoxide dismutase enzymes in kidney tissue. Conclusion: The results of the study showed that the native Iranian probiotics mixture can be used to protect the function and structure of the kidneys against toxic and oxidative damage induced by PbAc.

Indexed as

InflammationKidneyLead acetateOxidative stressProbiotic

Identifiers

PMID40255945

DOI10.22038/AJP.2024.24261

PMCPMC12009016

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