ArticleIDCases2025
Meningoencephalitis in a background of inherited chromosomic integration of HHV-6 and CMV infection in an immunocompetent adult, which one is the culprit?
Article in IDCases, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Authors and funding
4 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
HHV-6 meningoencephalitis has been reported in immunocompromised individuals but is very uncommon in immunocompetent individuals. However, HHV-6 is the second most frequently detected virus in multiplex PCR tests. As HHV-6 DNA integrates in the telomeric region of host chromosomes after primary infection and can be passed onto offspring, 1 % of the population carries an inherited HHV-6 genome (iciHHV-6). This makes it difficult to interpret a positive multiplex PCR test for HHV-6. Here, we describe a 39-year-old female patient with an unremarkable medical history and who was hospitalized for meningoencephalitis. The brain imaging findings were normal. The positive multiplex PCR test for HHV-6 was confirmed by qualitative and quantitative HHV-6 PCR tests, the viral load was higher in blood than in CSF. The presence of circulating anti-CMV IgM and IgG in a serologic test and the absence of other pathogens argued in favor of a primary CMV infection. However CMV PCR was negative. The chromosomal integration of HHV-6 was subsequently confirmed by the results of a hair bulb analysis. Our primary hypothesis was CMV meningoencephalitis in a context of inherited chromosomic integration of HHV-6 without be able to confirm the possible role of HHV-6 (reactivation or bystander) in this situation. A commercially available assay able to certify HHV-6 replication in a context of iciHHV-6 would have been useful to conclude.
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