ArticleFrontiers in neurology2025
Association of free-water imaging data for the cholinergic nucleus with the motor function and subtypes in Parkinson's disease.
Article in Frontiers in neurology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Background: Despite the importance of clinical heterogeneity in Parkinson's disease (PD), its underlying pathophysiology remains unclear. Objective: This study aimed to distinguish the association of free-water (FW) imaging data for the cholinergic nuclei with the motor subtypes of PD. Methods: The study included 150 cases of idiopathic PD from the Parkinson's Progression Markers Initiative cohort. FW imaging, including FW-corrected diffusion tensor imaging, was used to extract structural metrics from cholinergic nucleus 4 (Ch4) in the basal forebrain and the pedunculopontine nucleus. The motor subtypes were classified as tremor-dominant (TD, Results: At baseline, FW value for Ch4 (FW-Ch4) was correlated with the tremor subscore, while FW-corrected fractional anisotropy in Ch4 (FA-t-Ch4) was negatively correlated with the rigidity subscore. However, the TD and non-TD groups showed no differences in cholinergic FW imaging data. Among the 84 patients who were followed-up, 36.36% (20/55) in the TD group and 34.48% (10/29) in the non-TD group showed a subtype shift after 4 years. Multivariate binary logistic regression analysis showed that the normalized FW value for Ch4 (nFW-Ch4) was a predictor of subtype at the 4-year follow-up ( Conclusion: Tremor and rigidity subscores were correlated with Ch4 FW imaging data. Moreover, Ch4 FW imaging predicted the motor subtype at the 4-year follow-up, especially identifying potential postural instability and gait difficulty (PIGD) subtype converters from the TD group.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.