Evidence map›Paper›PMID 40255860›Full record

ReviewFrontiers in neuroscience2025

Model systems for emulating human tissue and physiology in psychiatric research.

Kai Cheng, Anannya Kshirsagar, John Nixon, Jonathan Lau, Kun Yang, Akira Sawa, Annie Kathuria

Abstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Frontiers in neuroscience, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Article
  2. Multi-Region Brain Organoids Integrating Cerebral, Mid-Hindbrain, and Endothelial Systems.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2025
    Article
  3. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Kai ChengDepartment of Biomedical Engineering, Whiting School of Engineering, Johns Hopkins University, Baltimore, MD, United States.
Anannya KshirsagarDepartment of Biomedical Engineering, Whiting School of Engineering, Johns Hopkins University, Baltimore, MD, United States.
John NixonDepartment of Biomedical Engineering, Whiting School of Engineering, Johns Hopkins University, Baltimore, MD, United States.
Jonathan LauDepartment of Biomedical Engineering, Whiting School of Engineering, Johns Hopkins University, Baltimore, MD, United States.
Kun YangDepartment of Psychiatry and Behavioral Sciences, Johns Hopkins School of Medicine, Baltimore, MD, United States.
Akira SawaDepartments of Psychiatry, Neuroscience, Mental Health, Pharmacology, Biomedical Engineering, and Genetic Medicine, Johns Hopkins University School of Medicine and Bloomberg School of Public Health, Johns Hopkins Medicine, Baltimore, MD, United States.
Annie KathuriaDepartment of Biomedical Engineering, Whiting School of Engineering, Johns Hopkins University, Baltimore, MD, United States.

Funding

Project 3P50MH136297 · NIMH · JOHNS HOPKINS UNIVERSITY · PI Elie Laurent Younes · 2024 to 2026
$12.8M
NIMH NIH HHS P50 MH136297
6 · The paper itself

Abstract

The modeling of psychiatric disorders poses significant challenges due to the complex nature of these conditions, which encompass a range of neuropsychiatric diseases such as autism spectrum disorder (ASD), schizophrenia (SCZ), bipolar disorder (BD), post-traumatic stress disorder (PTSD), anxiety disorder (AD) and depression. The rising global prevalence of mental disorders and the urgency for more effective treatments have propelled the development of innovative

Indexed as

3D organoid modelscomputational modelingiPSCregenerative medicinetissue engineering

Identifiers

PMID40255860
PMCPMC12006051

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.