ArticleLocal and regional anesthesia2025
Effectiveness of Combining Lidocaine and Ropivacaine on the Duration of Analgesia and Anesthesia of an Infraclavicular Brachial Plexus Block.
Article in Local and regional anesthesia, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
2 citing papers in PubMed.
- Pharmacological Interventions in the Management of Sports Injuries: A Review of Clinical Use, Dosage Forms, and Anti-Doping Considerations.Drug design, development and therapy · 2026Review
- Peri-Operative Surgical and Anaesthetic Predictors of Autogenous Arteriovenous Fistula (AVF) Maturation: A Retrospective Cohort Analysis.Vascular health and risk management · 2026Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
9 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Background: Combining local anesthetics for peripheral nerve blocks may change block characteristics, resulting in altered onset and block duration. We aimed to investigate the block characteristics of an infraclavicular brachial plexus block regarding block duration, pain after block cessation, and patient satisfaction by using a combination of lidocaine-epinephrine and ropivacaine. Methods: In this retrospective cohort study, 103 patients undergoing ambulatory hand or wrist surgery received an infraclavicular brachial plexus block with either a combination of ropivacaine 5 mg/mL combined with lidocaine 20 mg/mL and epinephrine 5 µg/mL (COMBI group) or only ropivacaine 5 mg/mL (ROPI group). The primary outcome was "Total block duration". Secondary outcomes were "Time until block begins to subside", "Pain after complete block cessation (Numerical Rating Scale 0-10)", and "Patient experience of nerve block". All outcomes were patient-reported. Multivariable regression analyses were used to adjust for predefined potential confounders. Results: "Total block duration" (mean ± SD) was 655±215 minutes in the COMBI group and 961±195 in the ROPI group; mean difference of 309 minutes; Conclusion: Combining lidocaine-epinephrine and ropivacaine reduced the duration of analgesia by approximately 5 hours. Pain after block cessation was moderately high in both groups.
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Registered trials
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