ArticleCureus2025
Two Cases of Levetiracetam-Induced Rhabdomyolysis With Low Levetiracetam Blood Concentrations.
Article in Cureus, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
2 citing papers in PubMed.
- Levetiracetam-Induced Rhabdomyolysis: An Alarming and Unexpected Turn in Seizure Management.Cureus · 2025Article
- Article
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Authors and funding
5 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Levetiracetam is an antiepileptic drug used to treat tonic-clonic convulsions and partial seizures. In general, levetiracetam is well tolerated; however, rhabdomyolysis has been reported as a rare side effect. The underlying mechanism is unclear. This case report describes two cases of rhabdomyolysis during levetiracetam treatment for convulsive status epilepticus, both of whom developed rhabdomyolysis a few days after starting levetiracetam. When levetiracetam was replaced with lacosamide, creatinine kinase decreased to the normal range within approximately 10 days. Furthermore, blood levels of levetiracetam were measured at the onset of rhabdomyolysis, and the results suggest that its adverse effects may not be correlated with its levels in the blood. Monitoring creatinine kinase is important for early detection of levetiracetam-induced rhabdomyolysis.
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