ArticleCureus2025
Intracranial Hybrid Neurofibroma/Schwannoma Arising From the Olfactory Groove: A Report of an Extremely Rare Case and Review of the Literature.
Article in Cureus, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
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Who cites it
3 citing papers in PubMed.
- Contemporary Profile of Hybrid Nerve Sheath Tumors: Clinical, Anatomical, and Imaging Characteristics.Cancers · 2026Article
- Foundation artificial intelligence models enable high-accuracy diagnostic differentiation of hybrid neurofibroma/schwannoma using whole-slide images.Journal of pathology informatics · 2026Article
- Hybrid neurofibroma/schwannoma in schwannomatosis-a diagnostically challenging benign peripheral nerve sheath tumour.Familial cancer · 2025Review
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Authors and funding
13 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Hybrid nerve sheath tumors (HNSTs) are rare peripheral nerve sheath tumors that combine the features of schwannomas, neurofibromas, and perineuriomas. Intracranial HNSTs are extremely rare. Herein, we report the first case of an intracranial hybrid neurofibroma/schwannoma arising from the olfactory groove. A 62-year-old woman presented with right-sided hemiparesis and a gait disturbance. Magnetic resonance imaging (MRI) revealed a 45×50 mm extra-axial mass in the left anterior cranial fossa, suggestive of a meningioma or schwannoma. The patient underwent bifrontal craniotomy with complete tumor removal. Histopathological and immunohistochemical studies confirmed that the tumor consisted of two components, a neurofibroma and a schwannoma, resulting in the diagnosis of a hybrid neurofibroma/schwannoma. Whole-genome sequencing of tumor DNA revealed somatic mutations in
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