Evidence map›Paper›PMID 40255691›Full record

ArticleBrain communications2025

Neurophysiological signatures of ageing: compensatory and compromised neural mechanisms.

Kamalini G Ranasinghe, Kiwamu Kudo, Kaitlin Casaletto, Julio C Rojas-Martinez, Faatimah Syed, Keith Vossel, Bruce L Miller, Gil D Rabinovici, Joel H Kramer, Katherine P Rankin and 1 more

Abstract read
In one paragraph

Article in Brain communications, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed.

  1. Article
  2. Review
  3. White matter hyperintensities are associated with locus coeruleus atrophy and astrocytic βAlzheimer's & dementia : the journal of the Alzheimer's Association · 2026
    Article
  4. Article
  5. Article
  6. Article
  7. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Kamalini G RanasingheDepartment of Neurology, Memory and Aging Center, University of California San Francisco, San Francisco, CA 94158, USA.ORCID https://orcid.org/0000-0002-4217-8785
Kiwamu KudoDepartment of Radiology and Biomedical Imaging, University of California San Francisco, San Francisco, CA 94143, USA.
Kaitlin CasalettoDepartment of Neurology, Memory and Aging Center, University of California San Francisco, San Francisco, CA 94158, USA.ORCID https://orcid.org/0000-0003-0610-6933
Julio C Rojas-MartinezDepartment of Neurology, Memory and Aging Center, University of California San Francisco, San Francisco, CA 94158, USA.
Faatimah SyedDepartment of Neurology, Memory and Aging Center, University of California San Francisco, San Francisco, CA 94158, USA.
Keith VosselDepartment of Neurology, David Geffen School of Medicine, Mary S. Easton Center for Alzheimer's Disease Research, University of California Los Angeles, Los Angeles, CA 90095, USA.
Bruce L MillerDepartment of Neurology, Memory and Aging Center, University of California San Francisco, San Francisco, CA 94158, USA.
Gil D RabinoviciDepartment of Neurology, Memory and Aging Center, University of California San Francisco, San Francisco, CA 94158, USA.
Joel H KramerDepartment of Neurology, Memory and Aging Center, University of California San Francisco, San Francisco, CA 94158, USA.
Katherine P RankinDepartment of Neurology, Memory and Aging Center, University of California San Francisco, San Francisco, CA 94158, USA.
Srikantan S NagarajanDepartment of Radiology and Biomedical Imaging, University of California San Francisco, San Francisco, CA 94143, USA.

Funding

In Vivo Studies of the Epileptic HippocampusRF1NS033310 · NINDS · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI ENGEL, JEROME NONE, STABA, RICHARD · 2023 to 2023
$3.6M
Preventing Seizures and Associated Memory Loss in Alzheimer's Disease by Blocking Tau Interactions with SH3-containing Proteins.R01AG058820 · NIA · UNIVERSITY OF MINNESOTA · PI VOSSEL, KEITH ALAN · 2019 to 2023
$1.9M
Leveraging the Electronic Health Record and Integrating Social and Biological Data to Expand Dementia Research in Understudied Populations in Los Angeles CountyUH2AG083254 · NIA · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI VOSSEL, KEITH ALAN · 2023 to 2024
$1.1M
NIA NIH HHS R01 AG058820NIA NIH HHS UH2 AG083254NINDS NIH HHS RF1 NS033310
6 · The paper itself

Abstract

Spatiotemporal patterns of neural oscillations change with ageing, even in the cognitively unimpaired individual. Whether these neurophysiological changes represent ageing-related vulnerabilities or mechanisms that support cognitive resilience remains largely unknown. In this study, we used magnetoencephalography imaging to examine age-related changes of resting-state whole-brain neurophysiology in a well-characterized cohort of cognitively unimpaired individuals (

Indexed as

aperiodic slopecompromised and compensatory brain changeshealthy ageingmagnetoencephalographyneural oscillations

Identifiers

PMID40255691
PMCPMC12006661

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.