ArticleBrain communications2025
Cerebral small vessel disease among rural-dwelling Chinese older adults: prevalence, distribution, and associated factors.
Article in Brain communications, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers, 1 of them a synthesis that pooled it.
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Who cites it
4 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Global ethnic disparities in cerebral small vessel disease imaging markers and vascular risk factors: a systematic review and meta-analysis.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2026Pooled it
- Multimorbidity burden and patterns associated with DeepBrainNet-derived brain-age gap in dementia-free older adults: A community-based study.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2026Article
- Association between minimum nocturnal heart rate and cerebral small vessel disease in patients with obstructive sleep apnea.Frontiers in aging neuroscience · 2026Article
- Serum Albumin as a Biomarker of Brain and Microvascular Health in Older Adults: Implications for Community-Based Aging Research.Journal of primary care & community healthArticle
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Authors and funding
14 authors.
Funding
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Abstract
Epidemiological characteristics of cerebral small vessel disease (cSVD) in the general population, especially among rural older adults, are poorly defined. Here, we reported the prevalence, distribution, and associated factors of cSVD in a rural-dwelling older population in China. This population-based cross-sectional study included 1272 older adults (age ≥60 years; mean age 69.43 years; 58.57% women) who underwent structural brain MRI scans (3.0T) in 2018-2020. MRI markers of cSVD were assessed following the Standards for Reporting Vascular Changes on Neuroimaging-1 criteria. We performed descriptive and regression analyses. The overall prevalence was 20.31% for cerebral microbleeds (CMBs), 26.87% for lacunes, 60.06% for basal ganglia perivascular spaces (PVS), 76.31% for centrum semiovale PVS, 95.74% for deep white matter hyperintensities (WMHs), and 94.17% for periventricular WMHs. The prevalence increased with advancing age for all cSVD markers, except PVS in the centrum semiovale. The prevalence of moderate-to-severe deep WMHs was higher in women than in men (
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