Evidence map›Paper›PMID 40255643›Full record

ArticleFrontiers in chemistry2025

Discovery of a novel 4-pyridyl SLC-0111 analog targeting tumor-associated carbonic anhydrase isoform IX through tail-based design approach with potent anticancer activity.

Hamada Hashem, Shadwa Abdelfattah, Hesham M Hassan, Ahmed Al-Emam, Mohammed Alqarni, Ghallab Alotaibi, Ibrahim Taha Radwan, Kirandeep Kaur, Devendra Pratap Rao, Stefan Bräse and 1 more

Abstract read
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In one paragraph

Article in Frontiers in chemistry, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Hamada HashemPharmaceutical Chemistry Department, Faculty of Pharmacy, Sohag University, Sohag, Egypt.
Shadwa AbdelfattahDepartment of Pharmaceutics and Industrial Pharmacy, Faculty of Pharmacy, Merit University (MUE), Sohag, Egypt.
Hesham M HassanDepartment of Pathology, College of Medicine, King Khalid University, Asir, Saudi Arabia.
Ahmed Al-EmamDepartment of Pathology, College of Medicine, King Khalid University, Asir, Saudi Arabia.
Mohammed AlqarniDepartment of Pharmaceutical chemistry, College of Pharmacy, Taif University, Taif, Saudi Arabia.
Ghallab AlotaibiDepartment of Pharmacology, College of Pharmacy, Shaqra University, Shaqra, Saudi Arabia.
Ibrahim Taha RadwanSupplementary General Sciences Department, Faculty of Oral and Dental Medicine, Future University in Egypt, Cairo, Egypt.
Kirandeep KaurDepartment of Chemistry, Maharaja Ranjit Singh Punjab Technical University, Bathinda, Punjab, India.
Devendra Pratap RaoCoordination Chemistry Laboratory, Department of Chemistry, Dayanand Anglo-Vedic (PG) College, Kanpur, Uttar Pradesh, India.
Stefan BräseInstitute of Biological and Chemical Systems, Functional Molecular Systems (IBCS-FMS), Karlsruhe Institute of Technology (KIT), Karlsruhe, Germany.
Abdullah AlkhammashDepartment of Pharmacology, College of Pharmacy, Shaqra University, Shaqra, Saudi Arabia.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

PubMed holds no abstract for this paper.

Indexed as

apoptosiscarbonic anhydrasecytotoxicitySLC-0111sulphonamide

Identifiers

PMID40255643
PMCPMC12006758

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.