Evidence map›Paper›PMID 40255593›Full record

ArticleFrontiers in medicine2025

Association of serum selenium levels with diabetic retinopathy: NHANES 2011-2016.

Xi Chen, Mei Sun, Zhenzhen Gu, Xiaofeng Hao, Like Xie

Abstract read
In one paragraph

Article in Frontiers in medicine, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Recent Progress in Selenium Nanomedicines for Ocular Diseases.International journal of nanomedicine · 2026
    Review
  2. Review
  3. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Xi Chen *Eye Hospital, China Academy of Chinese Medical Sciences, Beijing, China.
Mei Sun *Eye Hospital, China Academy of Chinese Medical Sciences, Beijing, China.
Zhenzhen GuEye Hospital, China Academy of Chinese Medical Sciences, Beijing, China.
Xiaofeng HaoEye Hospital, China Academy of Chinese Medical Sciences, Beijing, China.
Like XieEye Hospital, China Academy of Chinese Medical Sciences, Beijing, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background: Several studies have established a clear link between serum selenium levels and various health outcomes. However, to date, only a few studies have found an association between serum selenium levels and diabetic retinopathy (DR). The exact link between them is unclear. We collected data from different patient populations. Methods: Data from 645 adults, collected through the National Health and Nutrition Examination Survey (NHANES) between 2011 and 2016, were analyzed. The association between serum selenium levels and the incidence of DR was assessed using binary logistic regression. Subgroup analysis, smoothed curve-fitting analysis, and propensity score weighting were used to investigate the association further. Results: According to the multivariate analysis, there was no statistically significant linear association between serum selenium levels and the probability of developing DR ( Conclusion: A U-shaped curve represents the link between serum selenium levels and DR. The incidence of DR is elevated in individuals with serum selenium levels that are either higher or lower than the optimal range.

Indexed as

cross-sectional studydiabetic retinopathyepidemiologyNHANESselenium

Identifiers

PMID40255593
PMCPMC12006169

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.