ArticleFrontiers in medicine2025
Analysis of the global burden and key risk factors of neonatal sepsis and other neonatal infections in 204 countries and territories, 1990-2021.
Article in Frontiers in medicine, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.
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Who cites it
5 citing papers in PubMed.
- Transforming central line associated blood stream infection prevention in neonates: Results from a multimodal quality improvement initiative.World journal of clinical pediatrics · 2026Article
- Review
- Diagnostic utility of serum ferritin in culture proven bacterial infection: an observational study.BMC infectious diseases · 2026Observational
- CBC ratios for early sepsis risk stratification in newborns: EOS/LOS versus non-septic controls.BMC pediatrics · 2026Article
- Global, regional, and national burden of neonatal sepsis and other neonatal infections attributable to low birth weight: a systematic analysis of deaths, and DALYs with predictions to 2031.Frontiers in pediatrics · 2025Article
Corrections and comments
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Authors and funding
8 authors.
Funding
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Abstract
Background: Neonatal infections, particularly neonatal sepsis, remain significant contributors to morbidity and mortality in pediatrics. This study aims to provide data support for health authorities to control neonatal infections by analyzing the burden of neonatal sepsis and other neonatal infectious (NSNIs) globally and the trends in their risk factors. Methods: This study is based on the Global Burden of Disease (GBD) database, reviewing the burden and trends of neonatal sepsis and other infectious diseases from 1990 to 2021 at global, regional, and national levels. Descriptive statistics and Joinpoint regression analyses were employed to assess incidence rates, prevalence rates, mortality rates, and Disability-Adjusted Life Years (DALYs), with the Average Annual Percent Change (AAPC) used to quantify these trends. Results: The findings reveal that from 1990 to 2021, the global incidence (AAPC = -0.8%, Conclusion: The analysis indicates that while the global burden of NSNIs has decreased, the situation remains serious in Africa and Southeast Asia, with a continuing rise in the burden of NSNIs in the Eastern Mediterranean and Western Pacific regions in recent years. Policymakers should prioritize improving healthcare facilities, increasing access to medical resources, and investing in maternal and neonatal care to effectively reduce the incidence of NSNIs.
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