Evidence map›Paper›PMID 40255288›Full record

ArticleJAR life2025

Mediating role of the body mass index in the prospective association between a healthy diet and evolution of asthma symptoms in elderly women.

Wassila Ait-Hadad, Annabelle Bédard, Laurent Orsi, Sébastien Chanoine, Orianne Dumas, Nasser Laouali, Nicole Le Moual, Bénédicte Leynaert, Valérie Siroux, Marie-Christine Boutron-Ruault and 1 more

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Article in JAR life, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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0citing papers in PubMed
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1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

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3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

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5 · Who and what money

Authors and funding

11 authors.

Wassila Ait-HadadUniversité Paris-Saclay, UVSQ, Univ. Paris-Sud, Inserm, Équipe d'Épidémiologie respiratoire intégrative, CESP Villejuif France.
Annabelle BédardUniversité Paris-Saclay, UVSQ, Univ. Paris-Sud, Inserm, Équipe d'Épidémiologie respiratoire intégrative, CESP Villejuif France.
Laurent OrsiUniversité Paris-Saclay, UVSQ, Univ. Paris-Sud, Inserm, Équipe d'Épidémiologie respiratoire intégrative, CESP Villejuif France.
Sébastien ChanoineInserm U1209, CNRS, University Grenoble Alpes, Institute for Advanced Biosciences (IAB), Team of Environmental Epidemiology applied to the Development and Respiratory Health Grenoble France.
Orianne DumasUniversité Paris-Saclay, UVSQ, Univ. Paris-Sud, Inserm, Équipe d'Épidémiologie respiratoire intégrative, CESP Villejuif France.
Nasser LaoualiInstitute of Biological Sciences (ISSB), UM6P Faculty of Medical Sciences, Mohammed VI Polytechnic University, Ben Guerir, Morocco Department of Biostatistics and Epidemiology, Morocco.
Nicole Le MoualUniversité Paris-Saclay, UVSQ, Univ. Paris-Sud, Inserm, Équipe d'Épidémiologie respiratoire intégrative, CESP Villejuif France.
Bénédicte LeynaertUniversité Paris-Saclay, UVSQ, Univ. Paris-Sud, Inserm, Équipe d'Épidémiologie respiratoire intégrative, CESP Villejuif France.
Valérie SirouxInserm U1209, CNRS, University Grenoble Alpes, Institute for Advanced Biosciences (IAB), Team of Environmental Epidemiology applied to the Development and Respiratory Health Grenoble France.
Marie-Christine Boutron-RuaultUniversité Paris-Saclay, UVSQ, Univ. Paris-Sud, Inserm, Gustave Roussy, Équipe "Exposome et Hérédité", CESP, 94805, Villejuif, 94800, France.
Raphaëlle VarrasoUniversité Paris-Saclay, UVSQ, Univ. Paris-Sud, Inserm, Équipe d'Épidémiologie respiratoire intégrative, CESP Villejuif France.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Objectives: Diet and obesity exhibit complex interrelationships with asthma, particularly among elderly women. We aimed to clarify the impact of healthy diet assessed by the Alternate Healthy Eating Index-2010 (AHEI-2010) on: 1) the incidence of asthma symptoms, and 2) among women with symptoms in 2011, the change in asthma symptoms, while accounting for the potential mediating role of BMI. Design: A nested case-control study on asthma with follow-up data. Setting: Within the French E3N cohort. Participants: 8621 elderly women (62 years on average in 1993). Measurements: Dietary data were collected in 1993 and 2005 using semi-quantitative questionnaires. Using the validated asthma symptom score assessed in 2011 and 2018, asthma symptom incidence among women with no asthma symptom in 2011 ( Results: After adjustment for potential confounders, we found a significant indirect effect of healthier diet on lower risk of asthma symptoms incidence mediated by lower BMI (OR for AHEI-2010 quintile 5 vs quintile 1 = 0.95 (0.92-0.97)), without significant total (OR=0.87 (0.66-1.10)) nor direct (OR=0.92 (0.71-1.15)) effects. Among women with asthma symptoms, we also found a significant indirect effect of healthier diet on reduced asthma symptoms mediated by lower BMI (OR for AHEI-2010 >median Conclusion: A healthy diet was associated with reduced risk of asthma symptoms over time, partly through a lower BMI.

Indexed as

AHEI-2010Asthma symptoms incidenceBody mass indexChange in asthma symptomCounterfactual frameworkMediation analyses

Identifiers

PMID40255288
PMCPMC12008553

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.