Hidden β-γ Dehydrogenation Products in Long-Chain Fatty Acid Oxidation Unveiled by NMR: Implications on Lipid Metabolism.

Simone Fabbian, Beatrice Masciovecchio, Elisabetta Schievano, Gabriele Giachin

Abstract read

In one paragraph

Article in ACS bio & med chem Au, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it

0cells of the map it votes in

0citing papers in PubMed

–field-weighted citation impact

1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Simone FabbianDepartment of Chemical Sciences, University of Padua, via F. Marzolo 1, 35131 Padova, Italy.

Beatrice MasciovecchioDepartment of Chemical Sciences, University of Padua, via F. Marzolo 1, 35131 Padova, Italy.

Elisabetta SchievanoDepartment of Chemical Sciences, University of Padua, via F. Marzolo 1, 35131 Padova, Italy.ORCID https://orcid.org/0000-0002-4781-9932

Gabriele GiachinDepartment of Chemical Sciences, University of Padua, via F. Marzolo 1, 35131 Padova, Italy.ORCID https://orcid.org/0000-0001-7550-0307

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

We present a comprehensive analysis of the initial α,β-dehydrogenation step in long-chain fatty acid β-oxidation (FAO). We focused on palmitoyl-CoA oxidized by two mitochondrial acyl-CoA dehydrogenases, very-long-chain acyl-CoA dehydrogenase (VLCAD) and acyl-CoA dehydrogenase family member 9 (ACAD9), both implicated in mitochondrial diseases. By combining MS and NMR, we identified the (2

Identifiers

PMID40255280

DOI10.1021/acsbiomedchemau.4c00140

PMCPMC12006827

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.