Evidence map›Paper›PMID 40255187›Full record

ReviewPlant, cell & environment2025

Structure and Functions of NDR1/HIN1-Like (NHL) Proteins in Plant Development and Response to Environmental Stresses.

Victoria Amato, Shantel Mahalath, Liyuan Zhang, Paul J Rushton, Qingxi J Shen

Abstract readReview
In one paragraph

Review in Plant, cell & environment, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Victoria AmatoSchool of Life Sciences, University of Nevada, Las Vegas, Las Vegas, Nevada, USA.
Shantel MahalathSchool of Life Sciences, University of Nevada, Las Vegas, Las Vegas, Nevada, USA.
Liyuan ZhangSchool of Life Sciences, University of Nevada, Las Vegas, Las Vegas, Nevada, USA.
Paul J RushtonSchool of Life Sciences, University of Nevada, Las Vegas, Las Vegas, Nevada, USA.
Qingxi J ShenSchool of Life Sciences, University of Nevada, Las Vegas, Las Vegas, Nevada, USA.ORCID http://orcid.org/0000-0001-9962-9519

Funding

This study is supported in part by a USDA grant (2018-67013-27421) to Qingxi J. Shen and Paul J. Rushton.
6 · The paper itself

Abstract

The NON-RACE-SPECIFIC DISEASE RESISTANCE 1/harpin-induced 1-LIKE (NHL) gene family plays pivotal roles, including pathogen resistance, abiotic stress tolerance, and developmental regulation, underscoring their functional versatility in developmental and physiological processes of plants. NHL proteins often localize to the plasma membrane and contain conserved motifs, including the LEA2 and transmembrane domains, enabling dynamic interactions with signalling molecules and transcription factors. The ability of NHL proteins to dimerize and oligomerize further enhances their regulatory potential in signalling pathways. This review explores the structural and functional diversity of NHL proteins including their localizations, interacting proteins, and responses to abiotic and biotic stresses, ion transportation, seed germination, and responses to phytohormones. Future research integrating phylogenetics, and advanced tools including artificial intelligence will unlock the full potential of this gene family for breeding climate-resilient crops and agricultural sustainability.

Indexed as

Plant DevelopmentPlant ProteinsStress, PhysiologicalGene Expression Regulation, PlantPlant Proteinsabiotic stressArabidopsisbiotic stressintrinsic disordered regionLEA2 domainNHL (NDR1/HIN1)Oryza sativa (rice)transmembrane domain

Identifiers

PMID40255187
PMCPMC12223711

What OpenQuestion holds

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LicenceCC BY
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.