Evidence map›Paper›PMID 40254739›Full record

ArticleRedox report : communications in free radical research2025

Zinc nanoparticles mitigate azoxystrobin and its nanoencapsulation-induced hepatic and renal toxicity in rats.

Nashwa Elshaer, Ahmed M Eldeeb, Ahmed A A Aioub, Ahmed S Hashem, Soumya Ghosh, Lamya Ahmed Alkeridis, Mohammed Ali Alshehri, Mustafa Shukry, Daklallah A Almalki, Hind A Alkhatabi and 4 more

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Article in Redox report : communications in free radical research, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors.

Nashwa ElshaerPlant Protection Department, Faculty of Agriculture, Zagazig University, Zagazig, Egypt.
Ahmed M EldeebPlant Protection Department, Faculty of Agriculture, Zagazig University, Zagazig, Egypt.
Ahmed A A AioubPlant Protection Department, Faculty of Agriculture, Zagazig University, Zagazig, Egypt.
Ahmed S HashemStored Product Pests Research Department, Plant Protection Research Institute, Agricultural Research Center, Kafr El-Sheikh, Egypt.
Soumya GhoshNatural & Medical Science Research Center, University of Nizwa, Nizwa, Oman.
Lamya Ahmed AlkeridisDepartment of Biology, College of Science, Princess Nourah Bint Abdulrahman University, Riyadh, Saudi Arabia.
Mohammed Ali AlshehriDepartment of Biology, Faculty of Science, University of Tabuk, Tabuk, Saudi Arabia.
Mustafa ShukryDepartment of Physiology, Faculty of Veterinary Medicine, Kafrelsheikh University, Kafrelsheikh, Egypt.
Daklallah A AlmalkiBiology Department, Faculty of Science and Arts, Al-Baha University, Al-Mikhwah, Saudi Arebia.
Hind A AlkhatabiDepartment of Biological Sciences, College of Science, University of Jeddah, Jeddah, Saudi Arabia.
Mohamed AfifiDepartment of Biological Sciences, College of Science, University of Jeddah, Jeddah, Saudi Arabia.
Ammar Al-FargaDepartment of Biological Sciences, College of Science, University of Jeddah, Jeddah, Saudi Arabia.
Mohamed A HendawyPlant Protection Department, Faculty of Agriculture, Zagazig University, Zagazig, Egypt.
Ahmed E A El-SobkiPlant Protection Department, Faculty of Agriculture, Zagazig University, Zagazig, Egypt.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

This study sought to ascertain if zinc nanoparticles (ZnNPs) could lessen the toxicity of azoxystrobin (AZ). This naturally occurring methoxyacrylate is one of the most often used fungicides in agriculture in male albino rats. Six sets of 60 mature male albino rats were randomly assigned: control (distilled water), Azoxystrobin formulation (AZOF), Azoxystrobin nano-formula (AZON), ZnNPs, AZOF + ZnNPs, and AZON + ZnNPs. Blood and tissues were obtained for further immunohistochemical, pathological, and biochemical examination. The results showed that exposure to AZOF and AZON significantly increased the levels of the oxidative stress indicators glutathione peroxidase (GPx), catalase (CAT), superoxide dismutase (SOD), and malondialdehyde (MDA). Additionally, AZOF significantly impacts liver function bioindicators, including aspartate aminotransferase (AST) and alanine aminotransferase (ALT) levels. AZOF and AZON induced damage to the liver and kidney by disrupting vascular dilatation and causing hemorrhages, apoptosis, inflammatory lymphocytes, and necrosis. Furthermore, co-administration of ZnNPs with fungicides (AZOF and AZON) can gently enhance the alterations of oxidative stress and liver function bioindicators levels. These findings showed that ZnNPs could help male rats receiving AZ treat their histologically abnormal liver and kidney.

Indexed as

KidneyLiverMetal NanoparticlesPyrimidinesStrobilurinsZincAnimalsCatalaseFungicides, IndustrialGlutathione PeroxidaseMaleMalondialdehydeOxidative StressRatsSuperoxide DismutaseazoxystrobinCatalaseFungicides, IndustrialGlutathione PeroxidaseMalondialdehydePyrimidinesStrobilurinsSuperoxide DismutaseZincantioxidant enzymesAzoxystrobinbiochemical parametershistopathological studyimmunohistochemical studynano-Azoxystrobinrenal toxicityzinc nanoparticles

Identifiers

PMID40254739
PMCPMC12010655

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.