Evidence map›Paper›PMID 40254707›Full record

ArticleArchives of toxicology2025

Unveiling CYP450 inhibition by the pesticide prothioconazole through integrated in vitro studies and PBPK modeling.

Icaro S Perovani, Priscila A Yamamoto, Rodrigo M da Silva, Norberto P Lopes, Natalia V de Moraes, Anderson R M de Oliveira

Abstract read
PubMed Publisher
In one paragraph

Article in Archives of toxicology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Review
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Icaro S Perovani *Departamento de Química, Faculdade de Filosofia Ciências e Letras de Ribeirão Preto, Universidade de São Paulo, USP Av. dos Bandeirantes, 3900, Ribeirão Preto, São Paulo, 14040-901, Brazil.ORCID 0000-0001-9947-7367
Priscila A Yamamoto *Center for Pharmacometrics and Systems Pharmacology, Department of Pharmaceutics, College of Pharmacy, University of Florida, 6550 Sanger Road, Orlando, FL, 32827, USA.ORCID 0000-0002-2805-7960
Rodrigo M da SilvaNúcleo de Pesquisas de Produtos Naturais e Sintéticos, Departamento de Ciências Biomoleculares, Faculdade de Ciências Farmacêuticas de Ribeirão Preto, Universidade de São Paulo, Ribeirão Preto, São Paulo, 14090-903, Brazil.ORCID 0000-0003-2983-4941
Norberto P LopesNúcleo de Pesquisas de Produtos Naturais e Sintéticos, Departamento de Ciências Biomoleculares, Faculdade de Ciências Farmacêuticas de Ribeirão Preto, Universidade de São Paulo, Ribeirão Preto, São Paulo, 14090-903, Brazil.ORCID 0000-0002-8159-3658
Natalia V de MoraesCenter for Pharmacometrics and Systems Pharmacology, Department of Pharmaceutics, College of Pharmacy, University of Florida, 6550 Sanger Road, Orlando, FL, 32827, USA. nataliademoraes@ufl.edu.ORCID 0000-0002-4389-058X
Anderson R M de OliveiraDepartamento de Química, Faculdade de Filosofia Ciências e Letras de Ribeirão Preto, Universidade de São Paulo, USP Av. dos Bandeirantes, 3900, Ribeirão Preto, São Paulo, 14040-901, Brazil. deoliveira@usp.br.ORCID 0000-0002-5305-8957

Funding

Conselho Nacional de Desenvolvimento Científico e Tecnológico 306186/2021-7Conselho Nacional de Desenvolvimento Científico e Tecnológico INCT-DATREM - 465571/2014-0Coordenação de Aperfeiçoamento de Pessoal de Nível Superior 001Fundação de Amparo à Pesquisa do Estado de São Paulo 2014/50945-4Fundação de Amparo à Pesquisa do Estado de São Paulo 2020/02139-0Fundação de Amparo à Pesquisa do Estado de São Paulo 2021/10098-4
6 · The paper itself

Abstract

Prothioconazole (PTC), a widely used triazole fungicide with low human toxicity, was evaluated for its potential to inhibit human cytochrome P450 (CYP450) enzymes and its implications for pesticide-drug interactions (PDI). Through in vitro assays, PTC demonstrated significant inhibition of CYP2C9, CYP2C19, and CYP3A, with inhibition constant (Ki) values ranging from 0.08 to 5.88 µmol L⁻

Indexed as

Cytochrome P-450 Enzyme InhibitorsFungicides, IndustrialModels, BiologicalTriazolesAdultAnimalsArea Under CurveComputer SimulationCytochrome P-450 Enzyme SystemDrug InteractionsHumansMaleMicrosomes, LiverRatsRats, Sprague-DawleyCytochrome P-450 Enzyme InhibitorsCytochrome P-450 Enzyme SystemFungicides, IndustrialprothioconazoleTriazolesCYP450FungicideInhibitionPBPK modelingProthioconazoleRisk assessment

Identifiers

PMID40254707

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.