Evidence map›Paper›PMID 40254701›Full record

ArticleProbiotics and antimicrobial proteins2026

Probiotic Lactobacillus rhamnosus GG Alleviates Prehypertension and Restores Gut Health and Microbiota in NaCl-Induced Prehypertensive Rats.

Anis Munira Zaharuddin, Azdayanti Muslim, Shafiq Aazmi, Mohd Yusri Idorus, Fayez A Almabhouh, Shu Yong Lim, Aswini Leela Loganathan, Qasim Ayub, Chun Wie Chong, Khalilah Abdul Khalil and 3 more

Abstract read
PubMed Publisher
In one paragraph

Article in Probiotics and antimicrobial proteins, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

Anis Munira ZaharuddinMicrobiome Health and Environment (MiHeaRT) Research Interest Group, Faculty of Applied Sciences, Universiti Teknologi MARA, 40450, Shah Alam, Selangor, Malaysia.
Azdayanti MuslimMicrobiome Health and Environment (MiHeaRT) Research Interest Group, Faculty of Applied Sciences, Universiti Teknologi MARA, 40450, Shah Alam, Selangor, Malaysia.
Shafiq AazmiMicrobiome Health and Environment (MiHeaRT) Research Interest Group, Faculty of Applied Sciences, Universiti Teknologi MARA, 40450, Shah Alam, Selangor, Malaysia. shafiqaazmi@uitm.edu.my.
Mohd Yusri IdorusInstitute of Medical Molecular Biotechnology, Faculty of Medicine, Universiti Teknologi MARA, Kampus Sungai Buloh, Jalan Hospital, 47000, Sungai Buloh, Selangor, Malaysia.
Fayez A AlmabhouhInstitute of Medical Molecular Biotechnology, Faculty of Medicine, Universiti Teknologi MARA, Kampus Sungai Buloh, Jalan Hospital, 47000, Sungai Buloh, Selangor, Malaysia.
Shu Yong LimMonash University Malaysia Genomics Facility, Monash University Malaysia, 47500, Subang Jaya, Selangor, Malaysia.
Aswini Leela LoganathanMonash University Malaysia Genomics Facility, Monash University Malaysia, 47500, Subang Jaya, Selangor, Malaysia.
Qasim AyubMonash University Malaysia Genomics Facility, Monash University Malaysia, 47500, Subang Jaya, Selangor, Malaysia.
Chun Wie ChongSchool of Pharmacy, Monash University Malaysia, 47500, Subang Jaya, Selangor, Malaysia.
Khalilah Abdul KhalilMicrobiome Health and Environment (MiHeaRT) Research Interest Group, Faculty of Applied Sciences, Universiti Teknologi MARA, 40450, Shah Alam, Selangor, Malaysia.
Nurunajah Ab GhaniAtta-Ur-Rahman Institute for Natural Product Discovery (AuRIns), Universiti Teknologi MARA, Kampus Puncak Alam, 42300, Bandar Puncak Alam, Selangor, Malaysia.
Siong Meng LimCollaborative Drug Discovery Research (CDDR) Group, Faculty of Pharmacy, Universiti Teknologi MARA, Cawangan Selangor, Kampus Puncak Alam, 42300, Bandar Puncak Alam, Selangor, Malaysia.
Kalavathy RamasamyCollaborative Drug Discovery Research (CDDR) Group, Faculty of Pharmacy, Universiti Teknologi MARA, Cawangan Selangor, Kampus Puncak Alam, 42300, Bandar Puncak Alam, Selangor, Malaysia.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Probiotics could be used as adjuvant treatments in prehypertension management to restore gut microbiota dysbiosis caused by a high-salt diet. This study investigated the antihypertensive effects of the probiotic Lactobacillus rhamnosus strain GG (LGG) on high-salt diet-induced prehypertensive rats. Eighteen Sprague-Dawley rats were assigned equally into three groups: normotensive fed on a normal diet (ND), prehypertensive induced on a 4% NaCl high-salt diet (HSD), and prehypertensive induced on an HSD treated with LGG at 1 × 10

Indexed as

Gastrointestinal MicrobiomeLacticaseibacillus rhamnosusPrehypertensionProbioticsAnimalsBlood PressureMaleRatsRats, Sprague-DawleySodium ChlorideSodium Chloride, DietarySodium ChlorideSodium Chloride, DietaryGut microbiotaLactobacillus rhamnosus GGPrehypertensionProbiotic

Identifiers

PMID40254701

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.