Evidence map›Paper›PMID 40254649›Full record

ArticleNPJ precision oncology2025

Foundation model-driven multimodal prognostic prediction in patients undergoing primary surgery for high-grade serous ovarian cancer.

Qiu Bi, Conghui Ai, Linhao Qu, Qingyin Meng, Qinqing Wang, Jing Yang, Ao Zhou, Wenwei Shi, Ying Lei, Yunzhu Wu and 3 more

Abstract read
In one paragraph

Article in NPJ precision oncology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

Qiu Bi *Department of Radiology, Jinshan Hospital, Fudan University, Shanghai, China.
Conghui Ai *Department of Radiology, Yunnan Cancer Hospital, the Third Affiliated Hospital of Kunming Medical University, Peking University Cancer Hospital Yunnan, Kunming, Yunnan, China.
Linhao Qu *Fudan University, Shanghai, China.
Qingyin Meng *Department of Pathology, Yunnan Cancer Hospital, the Third Affiliated Hospital of Kunming Medical University, Peking University Cancer Hospital Yunnan, Kunming, Yunnan, China.
Qinqing Wang *Department of Pathology, the First People's Hospital of Yunnan Province, the Affiliated Hospital of Kunming University of Science and Technology, Kunming, Yunnan, China.
Jing YangDepartment of MRI, the First People's Hospital of Yunnan Province, the Affiliated Hospital of Kunming University of Science and Technology, Kunming, Yunnan, China.
Ao ZhouDepartment of Radiology, the First Affiliated Hospital of Chongqing Medical University, Chongqing, China.
Wenwei ShiDepartment of Radiology, Zhongda Hospital, School of Medicine, Southeast University, Nanjing, Jiangsu, China.
Ying LeiDepartment of Radiology, Zhongda Hospital, School of Medicine, Southeast University, Nanjing, Jiangsu, China.
Yunzhu WuDepartment of Radiology, Zhongda Hospital, School of Medicine, Southeast University, Nanjing, Jiangsu, China.
Yang LiuDepartment of Radiology, the First Affiliated Hospital of Chongqing Medical University, Chongqing, China. 249572846@qq.com.
Haiming LiDepartment of Radiology, Fudan University Shanghai Cancer Center, Shanghai, China; Department of Oncology, Shanghai Medical College, Fudan University, Shanghai, China. lihaiming0109@163.com.
Jinwei QiangDepartment of Radiology, Jinshan Hospital, Fudan University, Shanghai, China. qiangjinwei@fudan.edu.cn.

Funding

Kunming University of Science and Technology & the First People's Hospital of Yunnan Province Joint Special Project on Medical Research KUST-KH2022027YNatural Science Foundation of Shanghai 22ZR1412500Shanghai Jinshan District Health Committee SZK2023A02the Basic Research on Application of Joint Special Funding of Science and Technology Department of Yunnan Province-Kunming Medical University 202301AY070001-084the National Natural Science Foundations of China 82460340, 82471943, 82471932, 82271940, 82160524
6 · The paper itself

Abstract

High-grade serous ovarian cancer (HGSOC) presents challenges in prognostic prediction. This study aimed to develop a universal foundation model-driven multimodal model (FoMu model) to assess the prognosis of HGSOC patients. We conducted a retrospective cohort study involving 712 eligible patients across four centers, collecting clinical, MRI, and hematoxylin and eosin (H&E)-stained whole slide images (WSIs) data. Pre-trained radiological and pathological foundation models were employed for feature precoding. Subsequently, we introduced unimodal and cross-modal adaptive aggregation networks to comprehensively model the features derived from each modality. Our findings revealed that both unimodal and cross-modal FoMu models exhibited superior and stable predictive capabilities for overall survival (OS) and progression-free survival (PFS). In summary, our study successfully developed a FoMu model that effectively integrates multimodal data to assess the prognoses of HGSOC patients, highlighting its potential for improving individualized patient management and clinical decision-making in future applications.

Identifiers

PMID40254649
PMCPMC12009961

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.