Evidence map›Paper›PMID 40254611›Full record

ArticleNPJ vaccines2025

A SpA+LukAB vaccine targeting Staphylococcus aureus evasion factors restricts infection in two minipig infection models.

Jan T Poolman, Victor J Torres, Dominique Missiakas, Suzanne P M Welten, Jeffrey Fernandez, Ashley L DuMont, Anna O'Keeffe, Sergey R Konstantinov, Brian Morrow, Peter Burghout and 9 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in NPJ vaccines, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed.

  1. Article
  2. Review
  3. Review
  4. Article
  5. Review
  6. Phenotypic and Genotypic Characterization ofPathogens (Basel, Switzerland) · 2025
    Article
  7. Veterinary sciences · 2025
    Review
  8. Microorganisms · 2025
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

19 authors.

Jan T PoolmanBacterial Vaccines Discovery and Early Development, Janssen Vaccines and Prevention B.V Archimedesweg 4-6, Leiden, The Netherlands.ORCID http://orcid.org/0000-0002-9583-8126
Victor J TorresDepartment of Microbiology, New York University School of Medicine, Alexandria Center for Life Science, New York, NY, USA.ORCID http://orcid.org/0000-0002-7126-0489
Dominique MissiakasHoward T. Ricketts Laboratory, Department of Microbiology, The University of Chicago, Lemont, IL, USA.
Suzanne P M WeltenBacterial Vaccines Discovery and Early Development, Janssen Vaccines and Prevention B.V Archimedesweg 4-6, Leiden, The Netherlands.ORCID http://orcid.org/0000-0002-8224-7984
Jeffrey FernandezBacterial Vaccines, Janssen Vaccines and Prevention B.V. Welsh & McKean Rds, Spring House, PA, USA.ORCID http://orcid.org/0000-0001-6950-6139
Ashley L DuMontDepartment of Microbiology, New York University School of Medicine, Alexandria Center for Life Science, New York, NY, USA.ORCID http://orcid.org/0000-0002-0280-1624
Anna O'KeeffeDepartment of Microbiology, New York University School of Medicine, Alexandria Center for Life Science, New York, NY, USA.
Sergey R KonstantinovBacterial Vaccines Discovery and Early Development, Janssen Vaccines and Prevention B.V Archimedesweg 4-6, Leiden, The Netherlands.
Brian MorrowBacterial Vaccines, Janssen Research and Development, Raritan, NJ, USA.
Peter BurghoutBacterial Vaccines Discovery and Early Development, Janssen Vaccines and Prevention B.V Archimedesweg 4-6, Leiden, The Netherlands.
Jan GrijpstraBacterial Vaccines Discovery and Early Development, Janssen Vaccines and Prevention B.V Archimedesweg 4-6, Leiden, The Netherlands.ORCID http://orcid.org/0009-0006-4712-5267
Miranda M C van BeersBacterial Vaccines Discovery and Early Development, Janssen Vaccines and Prevention B.V Archimedesweg 4-6, Leiden, The Netherlands.ORCID http://orcid.org/0009-0000-1543-6438
Chakkumkal AnishBacterial Vaccines Discovery and Early Development, Janssen Vaccines and Prevention B.V Archimedesweg 4-6, Leiden, The Netherlands.
Michel BeurretBacterial Vaccines Discovery and Early Development, Janssen Vaccines and Prevention B.V Archimedesweg 4-6, Leiden, The Netherlands.ORCID http://orcid.org/0000-0002-4623-8896
Jeroen GeurtsenBacterial Vaccines Discovery and Early Development, Janssen Vaccines and Prevention B.V Archimedesweg 4-6, Leiden, The Netherlands.
Pauline M L RoodBacterial Vaccines Discovery and Early Development, Janssen Vaccines and Prevention B.V Archimedesweg 4-6, Leiden, The Netherlands.ORCID http://orcid.org/0009-0006-3591-3629
Oliver KoeberlingBacterial Vaccines Discovery and Early Development, Janssen Vaccines and Prevention B.V Archimedesweg 4-6, Leiden, The Netherlands.ORCID http://orcid.org/0009-0001-7386-9255
Miaomiao ShiHoward T. Ricketts Laboratory, Department of Microbiology, The University of Chicago, Lemont, IL, USA.
Germie P J M van den DobbelsteenBacterial Vaccines Discovery and Early Development, Janssen Vaccines and Prevention B.V Archimedesweg 4-6, Leiden, The Netherlands. gvanden@its.jnj.com.ORCID http://orcid.org/0009-0009-3703-9842

Funding

Vaccine Assembly from Surface Proteins of Staphylococcus AureusR01AI052474 · NIAID · UNIVERSITY OF CHICAGO · PI Dominique Missiakas · 2002 to 2026
$8.8M
NIAID NIH HHS R01 AI052474
6 · The paper itself

Abstract

Staphylococcus aureus is a major cause of bacterial infection-related deaths. Increasing antimicrobial resistance highlights the urgent need for effective preventative strategies. Antibody-mediated opsonophagocytosis, the key mechanism for protection against S. aureus, is disabled by critical virulence factors such as Staphylococcal protein A (SpA) and leukocidin AB (LukAB). In our study, we combined genetically detoxified vaccine candidates SpA* and LukAB RARPR-33 with a T

Identifiers

PMID40254611
PMCPMC12009994

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.