Evidence map›Paper›PMID 40254434›Full record

ArticleInternal medicine (Tokyo, Japan)2025

Acute Myeloid Leukemia with MYC Amplification on a Ring Chromosome 8.

Yuta Baba, Hirotaka Sakai, Nodoka Maeda, Maasa Abe, Nobuyuki Kabasawa, Tetsuya Fukuda

Abstract readCase Reports
PubMed Full text at PMC Publisher
In one paragraph

Article in Internal medicine (Tokyo, Japan), 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Yuta BabaDivision of Hematology, Department of Medicine, Showa Medical University Fujigaoka Hospital, Japan.
Hirotaka SakaiDivision of Hematology, Department of Medicine, Showa Medical University Fujigaoka Hospital, Japan.
Nodoka MaedaDivision of Hematology, Department of Medicine, Showa Medical University Fujigaoka Hospital, Japan.
Maasa AbeDivision of Hematology, Department of Medicine, Showa Medical University Fujigaoka Hospital, Japan.
Nobuyuki KabasawaDivision of Hematology, Department of Medicine, Showa Medical University Fujigaoka Hospital, Japan.
Tetsuya FukudaDivision of Hematology, Department of Medicine, Showa Medical University Fujigaoka Hospital, Japan.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

MYC amplification and overexpression are uncommon in acute myeloid leukemia (AML). An 82-year-old man developed leukocytosis during monoclonal gammopathy of renal significance. A chromosomal analysis revealed 46,XY,+r(8)[20]. Amplified MYC signals were detected on chromosome 8. The patient was diagnosed with AML and administered venetoclax and azacitidine. After the third course, clones with ring chromosome 8 had decreased in number, but clones unrelated to t(8;21)(q22;q22) had subsequently emerged. After the sixth course, the white blood cell count had markedly increased, and a chromosome analysis showed replacement of ring chromosome 8 with 46,XY,t(8;21)[20]. This case highlights the role of MYC amplification and overexpression in AML and suggests that BCL2 inhibition is a potential treatment.

Indexed as

Chromosomes, Human, Pair 8Gene AmplificationLeukemia, Myeloid, AcuteProto-Oncogene Proteins c-mycRing ChromosomesAged, 80 and overHumansMaleProto-Oncogene Proteins c-mycacute myeloid leukemiaBCL2 inhibitorMYCring chromosomeunrelated clone

Identifiers

PMID40254434
PMCPMC12659942

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.